(R)-1-Boc-2-甲基吡咯烷合成路线 （共 13 条）
反应条件
1: 96 percent / HCl gas / ethyl acetate / 2 h / 20 °C 2: K2CO3 / acetonitrile / 6 h / Heating 3: CuI; (i-Pr)2NH / PdCl2(PPh3)2 / acetonitrile / 20 °C View Scheme
参考文献
Ku, Yi-Yin; Pu, Yu-Ming; Grieme, Tim; Sharma, Padam; Bhatia, Ashok V.; Cowart, Marlon
Tetrahedron, 2006 , vol. 62, # 18 p. 4584 - 4589
反应条件
hydrogenchloride in 1,4-dioxane 0.5 h;
参考文献
ARENA PHARMACEUTICALS, INC.; PARK, Douglas, M.
Patent: WO2008/5338 A1, 2008 ;
Location in patent: Page/Page column 80 ;
WO 2008/005338 A1
反应条件
1: 96 percent / HCl gas / ethyl acetate / 2 h / 20 °C
2: K2CO3 / acetonitrile / 6 h / Heating
View Scheme
参考文献
Ku, Yi-Yin; Pu, Yu-Ming; Grieme, Tim; Sharma, Padam; Bhatia, Ashok V.; Cowart, Marlon
Tetrahedron, 2006 , vol. 62, # 18 p. 4584 - 4589
