(R)-1-Boc-2-甲基吡咯烷合成路线 （共 13 条）
反应条件
hydrogen; triethylamine; palladium on activated charcoal in methanol T=20°C;
参考文献
Ku, Yi-Yin; Pu, Yu-Ming; Grieme, Tim; Sharma, Padam; Bhatia, Ashok V.; Cowart, Marlon
Tetrahedron, 2006 , vol. 62, # 18 p. 4584 - 4589
反应条件
lithium triethylborohydride in tetrahydrofuran Heating;
参考文献
Ku, Yi-Yin; Pu, Yu-Ming; Grieme, Tim; Sharma, Padam; Bhatia, Ashok V.; Cowart, Marlon
Tetrahedron, 2006 , vol. 62, # 18 p. 4584 - 4589
反应条件
1: N-(tert-butoxycarbonyl)-2-trimethylstannylpyrrolidine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2 h; 2: dimethyl sulfate in tetrahydrofuran; hexane T=-78°C; Further stages. Title compound not separated from byproducts.;
参考文献
Journal of the American Chemical Society, , vol. 123, # 2 p. 315 - 321
反应条件
1: 96 percent / Et3N / CH2Cl2 / 12 h / 20 °C 2: 54 percent / LiEt3BH / tetrahydrofuran / Heating View Scheme
参考文献
Tetrahedron, , vol. 62, # 18 p. 4584 - 4589
反应条件
1: N-Boc-pyrrolidine With sec.-butyllithium; (+)-sparteine surrogate in diethyl ether; hexane T=-30°C; 0.0333333 h; 2: dimethyl sulfate in diethyl ether; hexane Overall yield = 55 percent; Overall yield = 102 mg; enantioselective reaction;
参考文献
Organic Letters, , vol. 15, # 21 p. 5424 - 5427
反应条件
sodium hydrogencarbonate in ethanol T=25°C; 15 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 8, # 20 p. 4533 - 4535
反应条件
1: dichloromethane / 0 - 20 °C / |Ionic liquid 2: (+)-sparteine surrogate; sec.-butyllithium / diethyl ether; hexane / 0.03 h / -30 °C View Scheme
参考文献
Organic Letters, , vol. 15, # 21 p. 5424 - 5427
反应条件
1: 94 percent / sodium borohydride; BF3*OEt2 / isopropyl acetate / -5 - 5 °C 2: DMAP; triethylamine / various solvent(s) / -5 - 0 °C 3: LiEt3BH / various solvent(s); tetrahydrofuran / -5 - 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 71, # 11 p. 4336 - 4338
反应条件
sec.-butyllithium; (-)-sparteine 1.) Et2O, -78 deg C, 6 h, 2.) Et2O, from -78 deg C to RT; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 116, # 8 p. 3231 - 3239
反应条件
hydrogenchloride in 1,4-dioxane 0.5 h;
参考文献
ARENA PHARMACEUTICALS, INC.; PARK, Douglas, M.
Patent: WO2008/5338 A1, 2008 ;
Location in patent: Page/Page column 80 ;
WO 2008/005338 A1
