6-重氮-5-氧代-L-正亮氨酸合成路线 （共 14 条）
反应条件
sodium hydroxide in methanol 0.5 h; Ambient temperature;
参考文献
Pettit, George R.; Nelson, Paul S.
Journal of Organic Chemistry, 1983 , vol. 48, # 5 p. 741 - 744
反应条件
piperidine 0.0333333 h;
参考文献
Coutts, Ian G. C.; Saint, Robert E.
Tetrahedron Letters, 1998 , vol. 39, # 20 p. 3242 - 3246
反应条件
1: 140 - 150 °C / Erhitzen des Reaktionsprodukts mit Acetanhydrid auf 100grad 2: methanol 3: ueber mehrere Stufen View Scheme
参考文献
Journal of the American Chemical Society, , vol. 80, p. 3941,3943
反应条件
1: methanol 2: ueber mehrere Stufen View Scheme
参考文献
Journal of the American Chemical Society, , vol. 80, p. 3941,3943
反应条件
2: 95 percent / 1) H2, 5percent palladium-carbon / 1) 95percent Ethanol, room temperature, 1 h, 2) Diethylether, cooling, overnight 3: 16 percent / 1) Oxalyl chloride / 0 °C / 1) methylene dichloride, 2) ether, 0.5 h 4: 88 percent / 1.0 N sodium hydroxide / methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, # 5 p. 741 - 744
反应条件
1: 95 percent / 1) H2, 5percent palladium-carbon / 1) 95percent Ethanol, room temperature, 1 h, 2) Diethylether, cooling, overnight 2: 16 percent / 1) Oxalyl chloride / 0 °C / 1) methylene dichloride, 2) ether, 0.5 h 3: 88 percent / 1.0 N sodium hydroxide / methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, # 5 p. 741 - 744
反应条件
1: 16 percent / 1) Oxalyl chloride / 0 °C / 1) methylene dichloride, 2) ether, 0.5 h 2: 88 percent / 1.0 N sodium hydroxide / methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, # 5 p. 741 - 744
反应条件
1: 22 percent / 1) Methanol / 1) methanol, room temperature, 48 h, 2) THF, 2 h and standing overnight in a refrigerator 2: 16 percent / 1) Oxalyl chloride / 0 °C / 1) methylene dichloride, 2) ether, 0.5 h 3: 88 percent / 1.0 N sodium hydroxide / methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, # 5 p. 741 - 744
反应条件
1: diethyl ether 2: TFA / CH2Cl2 3: N-methylmorpholine / 0 °C 4: diethyl ether 5: 4M NaOH View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 24 p. 2795 - 2798
反应条件
1: TFA / CH2Cl2 2: N-methylmorpholine / 0 °C 3: diethyl ether 4: 4M NaOH View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 24 p. 2795 - 2798
