3-(3-氟苯基)丙-1-醇合成路线 (共 12 条)
反应条件
magnesium; ethylene dibromide 1.) ether, reflux, 1 h; 2.) ether, RT, 24 h; Yield given. Multistep reaction;
参考文献
Parlow, John J.
Tetrahedron, 1994 , vol. 50, # 11 p. 3297 - 3314
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-78°C; 0.25 h; Inert atmosphere; 2: With triethylamine in dichloromethane T=-78 - 20°C; 1.25 h;
参考文献
Cinelli, Maris A.; Li, Huiying; Chreifi, Georges; Martasek, Pavel; Roman, Linda J.; Poulos, Thomas L.; Silverman, Richard B.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 4 p. 1513 - 1530