4-氨基-1,2,5-噁二唑-3-甲腈合成路线 （共 5 条）
反应条件
Pb3O4 in acetic acid T=20 - 65°C; 2.5 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/19190 A2, 2005 ;
Location in patent: Page/Page column 44-45 ;
WO 2005/019190 A2
反应条件
lead dioxide in acetic acid
参考文献
Chemistry - A European Journal, , vol. 15, # 11 p. 2625 - 2634
反应条件
lead dioxide; acetic acid 1.5 h; Ambient temperature;
参考文献
Andrianov, V. G.; Eremeev, A. V.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1994 , vol. 30, # 5 p. 608 - 611
Khimiya Geterotsiklicheskikh Soedinenii, 1994 , # 5 p. 693 - 696
反应条件
sodium methylate T=0 - 5°C; Addition; 1 h;
参考文献
Tselinskii; Mel'nikova; Pirogov; Sergievskii
Russian Journal of Organic Chemistry, 1999 , vol. 35, # 2 p. 296 - 300
参考文献
Russian Chemical Bulletin, , vol. 43, # 3 p. 402 - 404
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 3 p. 444 - 446
