4-羟基-8-甲氧基-2-甲基喹啉合成路线 （共 8 条）
反应条件
in diphenylether T=235°C; 3 h;
参考文献
Sawada, Yuki; Kayakiri, Hiroshi; Abe, Yoshito; Imai, Keisuke; Mizutani, Tsuyoshi; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Katayama, Akira; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1617 - 1630
反应条件
1: 99.8 percent / AcOH / benzene / 8 h / Heating 2: 48.7 percent / diphenyl ether; various solvent(s) / 3 h / 235 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 7 p. 1617 - 1630
反应条件
diethyl ether und Erhitzen des Reaktionsprodukts auf 260grad;
参考文献
DE42276 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 1, p. 204
Chemische Berichte, , vol. 21, p. 1652
反应条件
phosphorus oxytribromide T=120°C; 0.666667 h;
参考文献
JERINI AG
Patent: WO2008/116620 A1, 2008 ;
Location in patent: Page/Page column 124 ;
WO 2008/116620 A1
反应条件
1: 81.9 percent / phosphorus oxychloride; N,N-dimethylaniline / 2 h / Heating 2: 70.4 percent / boron tribromide / 2 h / Heating 3: 83.6 percent / dioxane / 6 h / Heating View Scheme
参考文献
Sawada, Yuki; Kayakiri, Hiroshi; Abe, Yoshito; Imai, Keisuke; Mizutani, Tsuyoshi; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Katayama, Akira; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1617 - 1630
反应条件
1: 81.9 percent / phosphorus oxychloride; N,N-dimethylaniline / 2 h / Heating 2: 70.4 percent / boron tribromide / 2 h / Heating View Scheme
参考文献
Sawada, Yuki; Kayakiri, Hiroshi; Abe, Yoshito; Imai, Keisuke; Mizutani, Tsuyoshi; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Katayama, Akira; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1617 - 1630
反应条件
N,N-dimethyl-aniline; trichlorophosphate 2 h; Heating;
参考文献
Sawada, Yuki; Kayakiri, Hiroshi; Abe, Yoshito; Imai, Keisuke; Mizutani, Tsuyoshi; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Katayama, Akira; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1617 - 1630
反应条件
1: 81.9 percent / phosphorus oxychloride; N,N-dimethylaniline / 2 h / Heating
2: 70.4 percent / boron tribromide / 2 h / Heating
3: 85.5 percent / dioxane / 6 h / Heating
View Scheme
参考文献
Sawada, Yuki; Kayakiri, Hiroshi; Abe, Yoshito; Imai, Keisuke; Mizutani, Tsuyoshi; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Katayama, Akira; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1617 - 1630
