6-氯-2-甲基-4-羟基喹啉合成路线 （共 13 条）
反应条件
trichlorophosphate Vilsmeier-Haack reaction; 17.5 h; Heating;
参考文献
Journal of the Indian Chemical Society, , vol. 81, # 7 p. 598 - 601
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=0 - 5°C; 1.5 h; 2: 6-chloro-2-methyl-quinolin-4-ol T=100°C; Vilsmeier-Haack reaction; 17.5 h;
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 42, # 9 p. 2069 - 2073
反应条件
1: phosphorus tribromide / N,N-dimethyl-formamide / 3 h / 0 - 20 °C
2: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C
3: selenium(IV) oxide / 1,4-dioxane / 2 h / 80 °C
View Scheme
参考文献
Gopinath, Vadiraj S.; Pinjari, Jakir; Dere, Ravindra T.; Verma, Aditya; Vishwakarma, Preeti; Shivahare, Rahul; Moger, Manjunath; Kumar Goud, Palusa Sanath; Ramanathan, Vikram; Bose, Prosenjit; Rao; Gupta, Suman; Puri, Sunil K.; Launay, Delphine; Martin, Denis
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 527 - 536
