1.1: s-BuLi; TMEDA / tetrahydrofuran; cyclohexane / 1 h / -78 °C 1.2: tetrahydrofuran; cyclohexane / 4 h / 40 °C 1.3: 96 percent / aq. HCl; NH4Cl / tetrahydrofuran; cyclohexane / 1 h / -40 - 20 °C 2.1: 78 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / Heating 3.1: 92 percent / LDA / tetrahydrofuran / 20 °C 4.1: n-BuLi / tetrahydrofuran; hexane / 0.08 h / 0 °C 4.2: 71 percent / tetrahydrofuran / -40 - 20 °C 5.1: 93 percent / aq. HCO2H; Pd(OAc)2; Ph3P / dimethylformamide / 60 - 70 °C View Scheme

1.1: 78 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / Heating 2.1: 92 percent / LDA / tetrahydrofuran / 20 °C 3.1: n-BuLi / tetrahydrofuran; hexane / 0.08 h / 0 °C 3.2: 71 percent / tetrahydrofuran / -40 - 20 °C 4.1: 93 percent / aq. HCO2H; Pd(OAc)2; Ph3P / dimethylformamide / 60 - 70 °C View Scheme

1.1: n-BuLi / tetrahydrofuran; hexane / 0.08 h / 0 °C 1.2: 71 percent / tetrahydrofuran / -40 - 20 °C 2.1: 93 percent / aq. HCO2H; Pd(OAc)2; Ph3P / dimethylformamide / 60 - 70 °C View Scheme

1.1: 92 percent / LDA / tetrahydrofuran / 20 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.08 h / 0 °C 2.2: 71 percent / tetrahydrofuran / -40 - 20 °C 3.1: 93 percent / aq. HCO2H; Pd(OAc)2; Ph3P / dimethylformamide / 60 - 70 °C View Scheme

1: methanol / 0.17 h / 60 °C 2: dirhodium tetraacetate; lithium tert-butylate / toluene / 1 h / 90 °C / Inert atmosphere; Molecular sieve View Scheme

1: KF*2H2O; palladium diacetate; PCy3∙HBF4 / tetrahydrofuran / Inert atmosphere 2: methanol / 0.17 h / 60 °C 3: dirhodium tetraacetate; lithium tert-butylate / toluene / 1 h / 90 °C / Inert atmosphere; Molecular sieve View Scheme

1: KF*2H2O; palladium diacetate; PCy3∙HBF4 / tetrahydrofuran / Inert atmosphere 2: methanol / 0.17 h / 60 °C 3: dirhodium tetraacetate; lithium tert-butylate / toluene / 1 h / 90 °C / Inert atmosphere; Molecular sieve View Scheme

暂无反应条件数据

(i) MeMgI, (ii) CoCl2; Multistep reaction;

P=150 Torr; durch Destillieren;