1-苄基氮杂环丁烷-3-酮合成路线 （共 9 条）
反应条件
sulfuric acid T=25°C; 3 h;
参考文献
De Smaele, Dirk; Dejaegher, Yves; Duvey, Guillaume; De Kimpe, Norbert
Tetrahedron Letters, 2001 , vol. 42, # 12 p. 2373 - 2375
反应条件
sulfur trioxide pyridine complex; triethylamine in dimethyl sulfoxide T=40°C; 0.5 h;
参考文献
Katritzky, Alan R.; Cundy, Darren J.; Chen, Jie
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 2 p. 271 - 276
反应条件
1: 98 percent / MgSO4 / CH2Cl2 / 0.5 h / 25 °C 2: 99 percent / Br2 / CH2Cl2 / 4 h / 0 °C 3: 52 percent / NaBH4 / 14 h / reflux 4: 63 percent / conc. H2SO4 / 3 h / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 12 p. 2373 - 2375
反应条件
1: 99 percent / Br2 / CH2Cl2 / 4 h / 0 °C 2: 52 percent / NaBH4 / 14 h / reflux 3: 63 percent / conc. H2SO4 / 3 h / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 12 p. 2373 - 2375
反应条件
1: petroleum ether / 3 h / Heating 2: triethylamine / acetonitrile / 72 h / Heating 3: 77 percent / CH3ONa / methanol / 1 h / Ambient temperature 4: 1.06 g / Py*SO3, Et3N / dimethylsulfoxide / 0.5 h / 40 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 2 p. 271 - 276
反应条件
1: triethylamine / acetonitrile / 72 h / Heating 2: 77 percent / CH3ONa / methanol / 1 h / Ambient temperature 3: 1.06 g / Py*SO3, Et3N / dimethylsulfoxide / 0.5 h / 40 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 2 p. 271 - 276
反应条件
1: 77 percent / CH3ONa / methanol / 1 h / Ambient temperature 2: 1.06 g / Py*SO3, Et3N / dimethylsulfoxide / 0.5 h / 40 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 2 p. 271 - 276
反应条件
1: 92 percent / petroleum ether / 48 h / Ambient temperature 2: petroleum ether / 3 h / Heating 3: triethylamine / acetonitrile / 72 h / Heating 4: 77 percent / CH3ONa / methanol / 1 h / Ambient temperature 5: 1.06 g / Py*SO3, Et3N / dimethylsulfoxide / 0.5 h / 40 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 2 p. 271 - 276
反应条件
1: 52 percent / NaBH4 / 14 h / reflux 2: 63 percent / conc. H2SO4 / 3 h / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 12 p. 2373 - 2375
