5-羟基-1,2-二甲基吲哚-3-羧酸乙酯合成路线 （共 10 条）
反应条件
in 1,2-dichloro-ethane T=20 - 60°C; Heating / reflux;
参考文献
EP1731506 A1, ;
Page/Page column 12; 16 ;
反应条件
1: ethyl acetoacetate; methylamine in methanol T=20°C; 2: p-benozquinone With acetic acid T=20°C; Nenitzescu reaction; Further stages.;
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 14 p. 3094 - 3102
参考文献
Journal of Organic Chemistry, , vol. 24, p. 1750
US2852527 , ;
反应条件
zinc(II) iodide in dichloromethane T=-30°C; Nenitzescu reaction; 15 h; Product distribution; Further Variations:SolventsReagents;
参考文献
Velezheva, Valeriya S.; Kornienko, Albert G.; Topilin, Sergey V.; Turashev, Ascar D.; Peregudov, Alexander S.; Brennan, Patrick J.
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 4 p. 873 - 879
反应条件
trifluoroacetic acid in dichloromethane Nenitzescu reaction;
参考文献
Velezheva, Valeriya S.; Kornienko, Albert G.; Topilin, Sergey V.; Turashev, Ascar D.; Peregudov, Alexander S.; Brennan, Patrick J.
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 4 p. 873 - 879
参考文献
Zhurnal Obshchei Khimii, , vol. 25, p. 1355; engl. Ausg. S. 1301
反应条件
1: aqueous NaOH; dioxane 2: ethanolic KOH View Scheme
参考文献
Grinew et al.
Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 447,450; engl. Ausg. S. 439, 441
反应条件
pyridine in acetone T=40 - 45°C;
参考文献
Shenyang Pharmaceutical University
Patent: EP1731506 A1, 2006 ;
Location in patent: Page/Page column 12; 16 ;
反应条件
potassium hydride in N,N-dimethyl-formamide
T=0 - 20°C; 4 h;
参考文献
Ferrer, Sandra; Naughton, Declan P.; Threadgill, Michael D.
Tetrahedron, 2003 , vol. 59, # 19 p. 3445 - 3454
反应条件
1,4-dioxane; sodium hydroxide
参考文献
Grinew et al.
Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 447,450; engl. Ausg. S. 439, 441
