N-[(3R)-1-(3,3-二甲基-2-氧代丁基)-2,3-二氢-2-氧代-5-(2-吡啶基)-1H-1,4-苯并二氮杂卓-3-基]-N’-[3-(甲基氨基)苯基]脲合成路线 （共 9 条）
反应条件
1: 93 percent / EDC, DMAP / CH2Cl2 / 0.33 h / 0 - 20 °C 2: sat. NH3 in MeOH / 1 h / Ambient temperature 3: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 1 h 4: 93 percent / gas. HBr / CH2Cl2 / 4 h / 0 °C 6: CH2Cl2 / 0.5 h / Ambient temperature 7: aq. HCl / ethyl acetate / 3 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 3 p. 331 - 341
反应条件
1: 91 percent / 2M aq. KOH / dioxane / Ambient temperature 2: 1.) NaH / 1.) DMF, from 10 deg C to RT, 1 h, 2.) DMF, RT, 2 h 3: acetone / 0.5 h 4: aq. NaN3 / acetone / 1 h 5: toluene / 2 h / Heating 6: CH2Cl2 / 0.5 h / Ambient temperature 7: aq. HCl / ethyl acetate / 3 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 3 p. 331 - 341
反应条件
1: 1.) NaH / 1.) DMF, from 10 deg C to RT, 1 h, 2.) DMF, RT, 2 h 2: acetone / 0.5 h 3: aq. NaN3 / acetone / 1 h 4: toluene / 2 h / Heating 5: CH2Cl2 / 0.5 h / Ambient temperature 6: aq. HCl / ethyl acetate / 3 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 3 p. 331 - 341
反应条件
1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 1 h 2: 93 percent / gas. HBr / CH2Cl2 / 4 h / 0 °C 4: CH2Cl2 / 0.5 h / Ambient temperature 5: aq. HCl / ethyl acetate / 3 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 3 p. 331 - 341
反应条件
2: CH2Cl2 / 0.5 h / Ambient temperature 3: aq. HCl / ethyl acetate / 3 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 3 p. 331 - 341
反应条件
1: acetone / 0.5 h 2: aq. NaN3 / acetone / 1 h 3: toluene / 2 h / Heating 4: CH2Cl2 / 0.5 h / Ambient temperature 5: aq. HCl / ethyl acetate / 3 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 3 p. 331 - 341
反应条件
1: CH2Cl2 / 0.5 h / Ambient temperature 2: aq. HCl / ethyl acetate / 3 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 3 p. 331 - 341
反应条件
1: CH2Cl2 / 0.5 h / Ambient temperature 2: aq. HCl / ethyl acetate / 3 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 3 p. 331 - 341
反应条件
1: 93 percent / gas. HBr / CH2Cl2 / 4 h / 0 °C 3: CH2Cl2 / 0.5 h / Ambient temperature 4: aq. HCl / ethyl acetate / 3 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 3 p. 331 - 341
