反应条件
1: tetrahydrofuran; diethyl ether / 2 h / -75 °C
2: hydrogenchloride / water; 1,3,5-trimethyl-benzene / 1 h / |Reflux
3: sodium methylate / tetrahydrofuran; methanol / 6 h / 20 °C
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BUSCH, Torsten; ANKLAM, Sven; JUNG, Joerg; OSTERMEIER, Markus
Patent: WO2014/20038 A1, 2014 ;