N-[(苄氧基)羰基]-L-组氨酸甲酯合成路线 （共 12 条）
反应条件
sodium hydroxide in methanol T=-20°C; 0.00833333 h;
参考文献
Boger, Dale L.; Teramoto, Shuji; Cai, Hui
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 179 - 193
反应条件
thionyl chloride T=25°C; 15 h;
参考文献
Boger, Dale L.; Teramoto, Shuji; Cai, Hui
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 179 - 193
反应条件
in dichloromethane Ambient temperature;
参考文献
Jones; Rathbone; Wyatt
Synthesis, 1987 , # 12 p. 1110 - 1113
反应条件
triethylamine 8 h; Heating;
参考文献
Nagao, Yoshimitsu; Miyasaka, Tadayo; Seno, Kaoru; Fujita, Eiichi; Shibata, Daisuke; Doi, Etsushiro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2439 - 2446
反应条件
1: 99 percent / SOCl2 / 36 h / 40 °C 2: 49 percent / aq. NaHCO3 / acetone / 12 h / 25 °C 3: 80 percent / 1N aq. NaOH / methanol / 0.01 h / -20 °C View Scheme
参考文献
Boger, Dale L.; Teramoto, Shuji; Cai, Hui
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 179 - 193
反应条件
1: 49 percent / aq. NaHCO3 / acetone / 12 h / 25 °C 2: 80 percent / 1N aq. NaOH / methanol / 0.01 h / -20 °C View Scheme
参考文献
Boger, Dale L.; Teramoto, Shuji; Cai, Hui
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 179 - 193
反应条件
1: 99 percent / Et3N / benzene / 1 h / 80 °C 2: 0.78 g / H2 / 10percent Pd/C / methanol / 2.5 h / 25 °C / 760 Torr 3: 98 percent / aq. NaHCO3 / tetrahydrofuran / 2 h / 25 °C 4: 85 percent / 0.1 N aq. LiOH / methanol / 2 h / 4 °C View Scheme
参考文献
Boger, Dale L.; Teramoto, Shuji; Cai, Hui
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 179 - 193
反应条件
1: 27 percent / triethylamine / ethyl acetate / 1.) 0 deg C, 1 h, 2.) room temp., 6 h. 2: 2.) 'constant boiling' hydrochloric acid / 1.) (DMF), 24 h, room temp., 2.) reflux, 24 h View Scheme
参考文献
Colombo, Roberto; Colombo, Fabio; Derome, Adrew E.; Jones, John H.; Rathbone, Daniel L.; Thomas, David W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1811 - 1816
反应条件
sodium periodate; ruthenium trichloride in tetrachloromethane; water; acetonitrile 60 h;
参考文献
Ranganathan, Subramania; Ranganathan, Darshan; Bhattacharyya, Dipti
Tetrahedron Letters, 1991 , vol. 32, # 40 p. 5615 - 5618
反应条件
1: 39 percent / triethylamine / benzene / 2 h / Heating 2: 2.) 'constant boiling' hydrochloric acid / 1.) (DMF), 24 h, room temp., 2.) reflux, 24 h View Scheme
参考文献
Colombo, Roberto; Colombo, Fabio; Derome, Adrew E.; Jones, John H.; Rathbone, Daniel L.; Thomas, David W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1811 - 1816
