8-[(1E)-2-(3,4-二甲氧基苯基)乙烯基]-1,3-二乙基-3,9-二氢-1H-嘌呤-2,6-二酮合成路线 （共 10 条）
反应条件
1: in acetonitrile Microwave irradiation; 2: With ammonium sulfate; hexamethyl-silane in acetonitrile T=160°C; 5 h; Microwave irradiation;
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
bromo-dimethylsulfonium bromide in acetonitrile T=25°C; 4 h; Inert atmosphere;
参考文献
Labeaume, Paul; Dong, Ma; Sitkovsky, Michail; Jones, Elizabeth V.; Thomas, Rhiannon; Sadler, Sara; Kallmerten, Amy E.; Jones, Graham B.
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 18 p. 4155 - 4157
反应条件
1: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in 1,4-dioxane; water 2: With sodium hydroxide Heating;
参考文献
Petzer, Jacobus P.; Steyn, Salome; Castagnoli, Kay P.; Chen, Jiang-Fan; Schwarzschild, Michael A.; Van Der Schyf, Cornelis J.; Castagnoli, Neal
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 7 p. 1299 - 1310
反应条件
1: 65 percent / pyridine / CH2Cl2 / 16 h / 20 °C 2: 92 percent / 1,1,1,3,3,3-hyxamethyldisilazane; (NH4)2SO4 / 4 h / 170 - 180 °C View Scheme
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
1: 80 percent / NH3; sodium dithionite / H2O / 60 °C 2: 65 percent / pyridine / CH2Cl2 / 16 h / 20 °C 3: 92 percent / 1,1,1,3,3,3-hyxamethyldisilazane; (NH4)2SO4 / 4 h / 170 - 180 °C View Scheme
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
1: 74 percent / acetic acid; NaNO2 / H2O / 0.25 h / 50 - 60 °C 2: 80 percent / NH3; sodium dithionite / H2O / 60 °C 3: 65 percent / pyridine / CH2Cl2 / 16 h / 20 °C 4: 92 percent / 1,1,1,3,3,3-hyxamethyldisilazane; (NH4)2SO4 / 4 h / 170 - 180 °C View Scheme
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
1.1: acetic acid / 2 h / 80 °C 2.1: sodium nitrite / acetic acid / 0.25 h / 50 - 60 °C 3.1: ammonium hydroxide; sodium dithionite / water / 0.5 h 4.1: pyridine / dichloromethane / 24 h / 20 °C 5.1: acetonitrile / |Microwave irradiation 5.2: 5 h / 160 °C / |Microwave irradiation View Scheme
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
1.1: thionyl chloride / toluene / 16 h / 75 °C 2.1: pyridine / dichloromethane / 24 h / 20 °C 3.1: acetonitrile / |Microwave irradiation 3.2: 5 h / 160 °C / |Microwave irradiation View Scheme
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
1.1: pyridine / dichloromethane / 24 h / 20 °C 2.1: acetonitrile / |Microwave irradiation 2.2: 5 h / 160 °C / |Microwave irradiation View Scheme
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.5 h;
参考文献
Labeaume, Paul; Dong, Ma; Sitkovsky, Michail; Jones, Elizabeth V.; Thomas, Rhiannon; Sadler, Sara; Kallmerten, Amy E.; Jones, Graham B.
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 18 p. 4155 - 4157
