(9ci)-1,2,6-三甲基-1H-苯并咪唑合成路线 （共 15 条）
参考文献
Chemische Berichte, , vol. 35, p. 1259
反应条件
sulfuric acid; acetic acid
T=110°C; 6 h;
参考文献
Skibo, Edward B.; Islam, Imadul; Heileman, Matthew J.; Schulz, William G.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 78 - 92
反应条件
hydrogenchloride; tin
Behandeln mit Eisessig;
参考文献
Fischer,O.; Rigaud
Chemische Berichte, 1902 , vol. 35, p. 1259
反应条件
1: trifluoroacetic acid / 1 h / Ambient temperature
2: KOH / acetone / 8 h / Heating
3: 81 percent / pyridine / CH2Cl2 / 8 h / Heating
4: 96 percent / H2 / 5percent Pd on charcoal / methanol / 4 h / 2585.7 Torr
5: 91 percent / acetic acid, conc. H2SO4 / 6 h / 110 °C
View Scheme
参考文献
Skibo, Edward B.; Islam, Imadul; Heileman, Matthew J.; Schulz, William G.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 78 - 92
反应条件
1: 96 percent / H2 / 5percent Pd on charcoal / methanol / 4 h / 2585.7 Torr
2: 91 percent / acetic acid, conc. H2SO4 / 6 h / 110 °C
View Scheme
参考文献
Skibo, Edward B.; Islam, Imadul; Heileman, Matthew J.; Schulz, William G.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 78 - 92
反应条件
1: KOH / acetone / 8 h / Heating
2: 81 percent / pyridine / CH2Cl2 / 8 h / Heating
3: 96 percent / H2 / 5percent Pd on charcoal / methanol / 4 h / 2585.7 Torr
4: 91 percent / acetic acid, conc. H2SO4 / 6 h / 110 °C
View Scheme
参考文献
Skibo, Edward B.; Islam, Imadul; Heileman, Matthew J.; Schulz, William G.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 78 - 92
参考文献
Green; Day
Journal of the American Chemical Society, 1942 , vol. 64, p. 1167,1170
反应条件
1: acetic acid; acetic acid anhydride; nitric acid / und Erhitzen des Reaktionsprodukts mit wss.Schwefelsaeure
2: pyridine
3: aqueous NaOH-solution
4: acetic acid; sulfuric acid
5: palladium; ethanol / Hydrogenation
6: sodium hydrogencarbonate; diethyl ether
7: toluene
View Scheme
参考文献
Green; Day
Journal of the American Chemical Society, 1942 , vol. 64, p. 1167,1170
反应条件
1: sodium hydrogencarbonate; diethyl ether
2: toluene
View Scheme
参考文献
Green; Day
Journal of the American Chemical Society, 1942 , vol. 64, p. 1167,1170
参考文献
Fischer,O.; Roemer
Journal fuer Praktische Chemie (Leipzig), 1906 , vol. <2> 73, p. 434
