2-氨基-4-氯-5-甲基苯甲酸合成路线 （共 13 条）
反应条件
potassium hydroxide; dihydrogen peroxide T=130°C; 2 h;
参考文献
Cancer Research Technology Limited
Patent: US6699861 B1, 2004 ;
Location in patent: Page column 15 ;
US 6699861 B1
反应条件
sodium hydroxide; dihydrogen peroxide in water 0.333333 h;
参考文献
Forsch, Ronald A.; Wright, Joel E.; Rosowsky, Andre
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 6 p. 2067 - 2076
反应条件
sodium hydroxide in water Reflux;
参考文献
Lockman, Jeffrey W.; Murphy, Brett R.; Zigar, Daniel F.; Judd, Weston R.; Slattum, Paul M.; Gao, Zhong-Hua; Ostanin, Kirill; Green, Jeremy; McKinnon, Rena; Terry-Lorenzo, Ryan T.; Fleischer, Tracey C.; Boniface, J. Jay; Shenderovich, Mark; Willardsen, J. Adam
Journal of Medicinal Chemistry, 2010 , vol. 53, # 24 p. 8734 - 8746
反应条件
1: 86 percent / pyridine / ethyl acetate / 18 h / 20 °C 2: 48 percent / glacial AcOH; Br2 / 1.5 h / 15 °C 3: 94 percent / AcOH; conc. HCl / 24 h / 118 °C 4: 6.52 g / N-methylpyrrolidinone / 2 h / 163 °C 5: 93 percent / aq. KOH; H2O2 / 2 h / 130 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 17 p. 3692 - 3702
反应条件
1: Na2SO4; H2NOH*HCl / H2O / 0.67 h / Heating 2: conc. H2SO4 / 60 - 80 °C 3: 80 percent / NaOH; 30 percent H2O2 / H2O / 0.33 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 6 p. 2067 - 2076
反应条件
1: conc. H2SO4 / 60 - 80 °C 2: 80 percent / NaOH; 30 percent H2O2 / H2O / 0.33 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 6 p. 2067 - 2076
反应条件
1: 48 percent / glacial AcOH; Br2 / 1.5 h / 15 °C 2: 94 percent / AcOH; conc. HCl / 24 h / 118 °C 3: 6.52 g / N-methylpyrrolidinone / 2 h / 163 °C 4: 93 percent / aq. KOH; H2O2 / 2 h / 130 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 17 p. 3692 - 3702
反应条件
1: 6.52 g / N-methylpyrrolidinone / 2 h / 163 °C 2: 93 percent / aq. KOH; H2O2 / 2 h / 130 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 17 p. 3692 - 3702
反应条件
1: 94 percent / AcOH; conc. HCl / 24 h / 118 °C 2: 6.52 g / N-methylpyrrolidinone / 2 h / 163 °C 3: 93 percent / aq. KOH; H2O2 / 2 h / 130 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 17 p. 3692 - 3702
反应条件
1: 97 percent / tetrahydrofuran / 6 h / 20 °C 2: 90 percent / DMAP / 3 h / 80 °C 3: 90 percent / pyridine / dimethylformamide / 2 h / 20 °C 4: 0.230 g / methanol; tetrahydrofuran / 26 h / 20 °C 5: 76 percent / 48percent aq. HBr / 7 h / 120 °C 6: 98 percent / DMAP; Et3N / CH2Cl2 / 0.5 h / 20 °C 7: 51 percent / NBS; dibenzoyl peroxide / CCl4 / 3.83 h / 85 °C / Irradiation 8: 73 percent / 2,6-lutidine / dimethylformamide / 5.5 h / 120 °C 9: 80 percent / aq. NaOH / tetrahydrofuran / 1 h / 20 °C 10: 94 percent / Et3N / CH2Cl2 / 0.92 h 11: 77 percent / CH2Cl2 / 2.5 h / 20 °C 12: 0.142 g / TFA / CH2Cl2 / 0.92 h / 20 °C 13: PyBOP; diisopropylethylamine / dimethylformamide / 3 h View Scheme
参考文献
Bavetsias; Skelton; Yafai; Mitchell; Wilson; Allan; Jackman
Journal of Medicinal Chemistry, 2002 , vol. 45, # 17 p. 3692 - 3702
