4-氯-2,6-二甲基-3-硝基吡啶合成路线 （共 12 条）
反应条件
trichlorophosphate in N,N-dimethyl-formamide; toluene T=110°C; 7 h;
参考文献
Huang, Yuhua; Bennett, Frank; Girijavallabhan, Vinay; Alvarez, Carmen; Chan, Tze-Ming; Osterman, Rebecca; Senior, Mary; Kwong, Cecil; Bansal, Namita; George Njoroge; MacCoss, Malcolm
Tetrahedron Letters, 2010 , vol. 51, # 21 p. 2800 - 2802
反应条件
trichlorophosphate in dichloromethane
反应条件
trichlorophosphate T=100°C; 10 h;
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Ishibe, Noriko; Sawada, Masae; Sakuma, Yuri; Hashimoto, Masaharu; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 22 p. 4408 - 4420
反应条件
1: 79 percent / 10 h / 180 °C 2: 87 percent / HCO2H, Pd / methanol / 10 h / Heating 3: 75 percent / 30 percent SO3/H2SO4, HNO3 / 72 h / Ambient temperature 4: 65 percent / POCl3 / 10 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 22 p. 4408 - 4420
反应条件
1: 87 percent / HCO2H, Pd / methanol / 10 h / Heating 2: 75 percent / 30 percent SO3/H2SO4, HNO3 / 72 h / Ambient temperature 3: 65 percent / POCl3 / 10 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 22 p. 4408 - 4420
反应条件
1: 75 percent / 30 percent SO3/H2SO4, HNO3 / 72 h / Ambient temperature 2: 65 percent / POCl3 / 10 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 22 p. 4408 - 4420
反应条件
1: 93 percent / triethylamine / propan-2-ol / 20 h / Heating 2: 98 percent / thionylchloride / CH2Cl2 / 2 h / Heating 3: 23 percent / 1.) triethylamine; 2.) ethanolic HCl / dimethylformamide / 2 h / Heating View Scheme
参考文献
Anagnostopulos, Hiristo; Bartlett, Robert R.; Elben, Ulrich; Stoll, Paul
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 227 - 232
反应条件
1: 41 percent / triethylamine / propan-2-ol / 20 h / Heating 2: 35 percent / 1.) triethylamine; 2.) ethanolic HCl / dimethylformamide / 2 h / Heating View Scheme
参考文献
Anagnostopulos, Hiristo; Bartlett, Robert R.; Elben, Ulrich; Stoll, Paul
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 227 - 232
反应条件
1: 93 percent / triethylamine / propan-2-ol / 20 h / Heating 2: 98 percent / thionylchloride / CH2Cl2 / 2 h / Heating 3: 20 percent / 1.) triethylamine; 2.) ethanolic HCl / dimethylformamide / 2 h / Heating View Scheme
参考文献
Anagnostopulos, Hiristo; Bartlett, Robert R.; Elben, Ulrich; Stoll, Paul
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 227 - 232
反应条件
1: ethanol / 5 h / Heating 2: H2, HCl / 5percent Pd/C / aq. ethanol / 2327.2 Torr 3: HCl / ethanol / 1.) 25 deg C, 5 h, 2.) reflux, 1.5 h 4: MnO2, 5 M NaOH / H2O / 0.83 h / pH 6 View Scheme
参考文献
Reich; Fabio; Lee; Kuck; Testa
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2474 - 2485
