2-氨基-4-甲氧基嘧啶合成路线 （共 14 条）
反应条件
hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10 on activated carbon in ethanol; ethyl acetate 14 h;
参考文献
S BIO PTE LTD
Patent: WO2009/93981 A1, 2009 ;
Location in patent: Page/Page column 104 ;
WO 2009/093981 A1
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane T=115°C; 21 h;
参考文献
WO2008/98058 A1, ;
Page/Page column 66-67 ;
WO 2008/098058 A1
反应条件
sodium T=5°C; 4 h; Reflux;
参考文献
Pan, Li; Jiang, Ying; Liu, Zhen; Liu, Xing-Hai; Liu, Zhuo; Wang, Gang; Li, Zheng-Ming; Wang, Di
European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 18 - 26
反应条件
in methanol T=20°C; 24 h;
参考文献
Linton, Angelica; Kang, Ping; Ornelas, Martha; Kephart, Susan; Hu, Qiyue; Pairish, Mason; Jiang, Ying; Guo, Chuangxing
Journal of Medicinal Chemistry, 2011 , vol. 54, # 21 p. 7705 - 7712
反应条件
ammonia; water Erwaermen des Reaktionsprodukts mit methanol.Natriummethylat;
参考文献
Journal of the American Chemical Society, , vol. 52, p. 1152,1156; vgl. H 24 80
Journal of the American Chemical Society, , vol. 56, p. 190,192
Zhurnal Obshchei Khimii, , vol. 27, p. 2113;engl.Ausg. S.2170
反应条件
3 h; RefluxInert atmosphere;
参考文献
WO2012/7345 A2, ;
Page/Page column 90; 91 ;
WO 2012/007345 A2
反应条件
ammonia 1) methanol; Multistep reaction;
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, p. 149 - 153
反应条件
1: alcohol; ammonia / 100 °C 2: zinc; aqueous-methanolic hydrochloric acid / 40 °C View Scheme
参考文献
Chemische Berichte, , vol. 36, p. 3383
反应条件
water 2 h; Irradiationvar. pH values; Product distributionRate constant;
参考文献
Journal of Agricultural and Food Chemistry, , vol. 44, # 10 p. 3379 - 3382
参考文献
Yakugaku Zasshi, , vol. 62, p. 315,333; dtsch. Ref. S. 95, 106
Chem.Abstr., , p. 5150
