3,4-二羟基-5-(6-氧代-3H-嘌呤-9-基)四氢呋喃-2-羧酸合成路线 （共 9 条）
反应条件
oxygen T=37°C; nucleoside oxidase from Pseudomonas maltophilia LB-86;
参考文献
Mahmoudian, Mahmoud; Rudd, Brian A.M.; Cox, Brian; Drake, Chris S.; Hall, Richard M.; Stead, Paul; Dawson, Michael J.; Chandler, Malcolm; Livermore, David G.; Turner, Nicholas J.; Jenkins, Gareth
Tetrahedron, 1998 , vol. 54, # 28 p. 8171 - 8182
反应条件
1: 100 percent / RuCl3*3H2O, NaIO4 / H2O; acetonitrile; CCl4 / Ambient temperature 2: glacial acetic acid / H2O / Heating; pH 2.3-2.4 View Scheme
参考文献
Singh, Ambarish K.; Varma, Rajender S.
Tetrahedron Letters, 1992 , vol. 33, # 17 p. 2307 - 2310
反应条件
oxygen T=37°C; nucleoside oxidase from Pseudomonas maltophilia LB-86;
参考文献
Isono, Yoshikazu; Sudo, Tomoko; Hoshino, Masami
Agricultural and Biological Chemistry, 1989 , vol. 53, # 6 p. 1663 - 1670
反应条件
oxygen nucleoside oxidase from Pseudomonas maltophilia LB-86;; Product distributionMechanism;
参考文献
Isono, Yoshikazu; Sudo, Tomoko; Hoshino, Masami
Agricultural and Biological Chemistry, 1989 , vol. 53, # 6 p. 1663 - 1670
反应条件
hydrogenchloride; sodium tetrahydroborate; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide multistep reaction; 1.) RT, 2 h; structural elucidation;
参考文献
Isono, Yoshikazu; Sudo, Tomoko; Hoshino, Masami
Agricultural and Biological Chemistry, 1989 , vol. 53, # 6 p. 1663 - 1670
反应条件
1: 78 percent / triethylamine, diphenylphosphoryl azide / dimethylformamide / 1.) -20 deg C, 1 h, 2.) 20 deg C, 20 h
2: NaNO2, formic acid / 0.5 h
View Scheme
参考文献
Montgomery, John A.; Thomas, H. Jeanette; Brockman, R. Wallace; Wheeler, Glynn P.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 2 p. 184 - 189
反应条件
1: 71 percent / triethylamine, diphenylphosphoryl azide / dimethylformamide / 1.) -20 deg C, 1 h, 2.) 20 deg C, 20 h
2: 22 percent / NaNO2, formic acid / 0.5 h
View Scheme
参考文献
Montgomery, John A.; Thomas, H. Jeanette; Brockman, R. Wallace; Wheeler, Glynn P.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 2 p. 184 - 189
反应条件
diphenylphosphoranyl azide; triethylamine in N,N-dimethyl-formamide
1.) -20 deg C, 1 h, 2.) 20 deg C, 20 h;
参考文献
Montgomery, John A.; Thomas, H. Jeanette; Brockman, R. Wallace; Wheeler, Glynn P.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 2 p. 184 - 189
反应条件
diphenylphosphoranyl azide; triethylamine in N,N-dimethyl-formamide
1.) -20 deg C, 1 h, 2.) 20 deg C, 20 h;
参考文献
Montgomery, John A.; Thomas, H. Jeanette; Brockman, R. Wallace; Wheeler, Glynn P.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 2 p. 184 - 189
