4-(二氟甲氧基)硝基苯合成路线 （共 23 条）
反应条件
1: 4-nitro-phenol With sodium hydroxide in DMF (N,N-dimethyl-formamide) T=20°C; 0.25 h; 2: ethyl chloro-difluoroacetate in DMF (N,N-dimethyl-formamide) T=0 - 70°C; 16 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2006/69097 A2, 2006 ;
Location in patent: Page/Page column 43 ;
WO 2006/069097 A2
反应条件
potassium hydroxide in water; acetonitrile T=-78 - 80°C; 4 h;
参考文献
Wang, Fei; Zhang, Laijun; Zheng, Ji; Hu, Jinbo
Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 521 - 528
反应条件
sodium hydroxide in DMF (N,N-dimethyl-formamide) T=0 - 70°C; 16.25 h;
参考文献
Schumacher, Richard; Danca, Mihaela Diana; Ma, Jianguo; Herbert, Brian; Nguyen, True Minh; Xie, Wenge; Tehim, Ashok
Patent: US2007/78147 A1, 2007 ;
Location in patent: Page/Page column 64 ;
反应条件
sodium hydroxide in 1-chloro-1,1-difluoro-methane; toluene
参考文献
Bayer Aktiengesellschaft
Patent: US5463138 A1, 1995 ;
反应条件
sodium hydroxide in N,N-dimethyl-formamide
参考文献
SmithKline Beecham Corporation
Patent: US5731477 A1, 1998 ;
反应条件
potassium carbonate in ethyl acetate; N,N-dimethyl-formamide
参考文献
SmithKline Beecham Corporation
Patent: US5731477 A1, 1998 ;
反应条件
potassium hydroxide in acetonitrile T=50°C;
参考文献
Zheng, Ji; Li, Ya; Zhang, Laijun; Hu, Jinbo; Meuzelaar, Gerrit Joost; Federsel, Hans-Juergen
Chemical Communications, 2007 , # 48 p. 5149 - 5151
反应条件
sodium hydroxide in 1,4-dioxane; water
反应条件
potassium hydroxide in water; acetonitrile T=-78 - 20°C; 0.333333 h;
参考文献
Zafrani, Yossi; Sod-Moriah, Gali; Segall, Yoffi
Tetrahedron, 2009 , vol. 65, # 27 p. 5278 - 5283
反应条件
C4H8O*5FH T=20°C; 12 h; Inert atmosphere; Reagent/catalystTemperatureTime;
参考文献
Journal of Fluorine Chemistry, , vol. 160, p. 72 - 76
