反应条件
1: 7-bromo-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine With n-butyllithium in tetrahydrofuran T=-78°C; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-78 - 20°C; 2 h;
参考文献
MERCK SHARP and DOHME CORP.; KOZLOWSKI, Joseph A.; ROSENBLUM, Stuart B.; COBURN, Craig A.; SHANKAR, Bandarpalle, B.; ANILKUMAR, G., Nair; CHEN, Lei; DWYER, Michael, P.; JIANG, Yueheng; KEERTIKAR, Kartik, M.; LAVEY, Brian, J.; SELYUTIN, Oleg, B.; TONG, Ling; WONG, Michael; YANG, De-Yi; YU, Wensheng; ZHOU, Guowei; WU, Hao; HU, Bin; ZHONG, Bin; SUN, Fei; JI, Tao; SHEN, Changmao; RIZVI, Razia; ZENG, Qingbei
Patent: WO2012/41014 A1, 2012 ;
Location in patent: Page/Page column 236-237 ;