N-[2-异丙基噻唑-4-甲基氨基甲酰]-L-缬氨酸合成路线 (共 11 条)
反应条件
1: With lithium hydroxide in tetrahydrofuran; water T=20°C; 1.5 h; 2: With hydrogenchloride; water in tetrahydrofuran
参考文献
GILEAD SCIENCES, INC.
Patent: WO2008/10921 A2, 2008 ;
Location in patent: Page/Page column 199-200 ;
反应条件
NaH in tetrahydrofuran; water; toluene
参考文献
Abbott Laboratories
Patent: US6160122 A1, 2000 ;
反应条件
sodium hydroxide in tetrahydrofuran; n-heptane; water; toluene
参考文献
Abbott Laboratories
Patent: US6160122 A1, 2000 ;
反应条件
hydrogenchloride in tetrahydrofuran; water; toluene
参考文献
Abbott Laboratories
Patent: US6160122 A1, 2000 ;
反应条件
hydrogenchloride in 1,4-dioxane; dichloromethane
参考文献
Abbott Laboratories
Patent: US5461067 A1, 1995 ;
US 5461067 A
反应条件
hydrogenchloride; NaH in tetrahydrofuran; water; toluene
反应条件
1: DMAP, Et3N / tetrahydrofuran / 2 h / Heating 2: 0.50 M aq. LiOH / dioxane / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 4 p. 602 - 617
反应条件
in tetrahydrofuran; n-heptane; water; toluene
参考文献
Abbott Laboratories
Patent: US6160122 A1, 2000 ;
反应条件
1: 4-methylmorpholine / CH2Cl2 / Ambient temperature 2: DMAP, Et3N / tetrahydrofuran / 2 h / Heating 3: 0.50 M aq. LiOH / dioxane / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 4 p. 602 - 617
反应条件
1: DMAP, Et3N / tetrahydrofuran / 2 h / Heating 2: 0.50 M aq. LiOH / dioxane / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 4 p. 602 - 617