4-(3-羟基丙基)苯甲酸甲酯合成路线 （共 8 条）
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
Varney, Michael D.; Palmer, Cindy L.; Romines III, William H.; Boritzki, Theodore; Margosiak, Stephen A.; Almassy, Robert; Janson, Cheryl A.; Bartlett, Charlotte; Howland, Eleanor J.; Ferre, Rosanne
Journal of Medicinal Chemistry, 1997 , vol. 40, # 16 p. 2502 - 2524
反应条件
thionyl chloride in methanol
参考文献
Bayer Aktiengesellschaft
Patent: US5041638 A1, 1991 ;
反应条件
1: 83 percent / CuI, (Ph3P)2PdCl2 / diethylamine / Ambient temperature 2: 95 percent / H2 / 5percent Pd-C / ethanol / 3.5 h / 2327.2 Torr View Scheme
参考文献
Taylor, Edward C.; Gillespie, Paul; Patel, Mona
Journal of Organic Chemistry, 1992 , vol. 57, # 11 p. 3218 - 3225
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene 1 h; Heating;
参考文献
Lee, Eun; Lee, Chulbom; Tae, Jin Sung; Whang, Ho Sung; Li, Kap Sok
Tetrahedron Letters, 1993 , vol. 34, # 14 p. 2343 - 2346
反应条件
1: K2CO3, 18-crown-6 / acetone / Heating 2: 25 percent / Bu3SnH, AIBN / benzene / 1 h / Heating View Scheme
参考文献
Lee, Eun; Lee, Chulbom; Tae, Jin Sung; Whang, Ho Sung; Li, Kap Sok
Tetrahedron Letters, 1993 , vol. 34, # 14 p. 2343 - 2346
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane 1.) 0 deg C, 30 min, 2.) RT, overnight;
参考文献
Varney, Michael D.; Palmer, Cindy L.; Romines III, William H.; Boritzki, Theodore; Margosiak, Stephen A.; Almassy, Robert; Janson, Cheryl A.; Bartlett, Charlotte; Howland, Eleanor J.; Ferre, Rosanne
Journal of Medicinal Chemistry, 1997 , vol. 40, # 16 p. 2502 - 2524
参考文献
Cameron, Kimberly O.; Lefker, Bruce A.
Patent: US2002/65308 A1, 2002 ;
US 20020065308 A1
反应条件
1: 97 percent / TEA / tetrahydrofuran / 3 h / 25 °C
2: 93 percent / NaN3 / dimethylformamide / 18 h / 25 °C
3: 98 percent / H2O, Ph3P / tetrahydrofuran / 18 h / 25 °C
View Scheme
参考文献
Taylor, Edward C.; Gillespie, Paul; Patel, Mona
Journal of Organic Chemistry, 1992 , vol. 57, # 11 p. 3218 - 3225
