BOC-脯氨酸基-脯氨酸合成路线 （共 12 条）
反应条件
lithium hydroxide hydrate
参考文献
Kroll, Carsten; Mansi, Rosalba; Braun, Friederike; Dobitz, Stefanie; Maecke, Helmut R.; Wennemers, Helma
Journal of the American Chemical Society, 2013 , vol. 135, # 45 p. 16793 - 16796
反应条件
hydrogen; palladium in methanol 48 h; Ambient temperature;
参考文献
Fukui, Hiroshi; Kanehisa, Hidenori; Ishibashi, Norio; Miyake, Ichizo; Okai, Hideo
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 3 p. 766 - 769
反应条件
sodium perchlorate; triethylamine in N,N-dimethyl-formamide T=20°C; Condensation; 2 h;
参考文献
Raydnov, M. G.; Klimenko, L. V.; Mitin, Yu. V.
Russian Journal of Bioorganic Chemistry, 1999 , vol. 25, # 5 p. 283 - 287
Bioorganicheskaya Khimiya, 1999 , vol. 25, # 5 p. 323 - 328
反应条件
1: 1.) N-methylmorpholine, 2.) DCC / 1.) CHCl3, 0 deg C, 15 min, 2.) CH2Cl2, room temperature, 24 h 2: LiOH / tetrahydrofuran; H2O / 1 h / Ambient temperature View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 37, # 4 p. 370 - 375
反应条件
1: Fmoc–Pro–OH With N-ethyl-N,N-diisopropylamine in dichloromethane 2-chlorotrityl chloride resin; 2: With piperidine in N,N-dimethyl-formamide 0.166667 h; 2-chlorotrityl chloride resin; 3: di-tert-butyl dicarbonate; Fmoc–Pro–OH Further stages;
参考文献
Kolesinska, Beata; Podwysocka, Dominika J.; Rueping, Magnus A.; Seebach, Dieter; Kamena, Faustin; Walde, Peter; Sauer, Markus; Windschiegl, Barbara; Meyer-Acs, Mira; Vor Der Brueggen, Marc; Giehring, Sebastian
Chemistry and Biodiversity, 2013 , vol. 10, # 1 p. 1 - 38
反应条件
1: NMM, DCC / acetonitrile, 0 deg C, overnight 2: 60 percent / H2 / Pd black / methanol View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 57, # 1 p. 97 - 102
反应条件
in tetrahydrofuran T=20°C; Basic conditions;
参考文献
Nowshuddin, Shaik; Ram Reddy
Tetrahedron Asymmetry, 2011 , vol. 22, # 1 p. 22 - 25
反应条件
1: N-methylmorpholine (NMM), 1-hydroxyl-1H-benzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC) / tetrahydrofuran / 0 - 20 °C 2: H2 / 5percent Pd/C / methanol; acetic acid / 760 Torr / Ambient temperature View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 53, # 4 p. 1028 - 1033
反应条件
1: 69.9 percent / DCC; Et3N / CHCl3 / 24 h / 20 °C 2: aq. LiOH / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Bollettino Chimico Farmaceutico, , vol. 138, # 4 p. 160 - 164
反应条件
1: sodium hydrogencarbonate / water; tetrahydrofuran / 2 h / 20 °C 2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C 3: sodium hydroxide / tetrahydrofuran / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 135, # 10 p. 3881 - 3886
