(S)-()-N-Boc-叔亮氨醇合成路线 （共 10 条）
反应条件
1: (2S)-2-amino-3,3-dimethylbutanoic acid With lithium aluminium tetrahydride in tetrahydrofuran 6 h; Heating / reflux; 2: With sodium hydroxide; water in tetrahydrofuran T=0 - 20°C; 0.166667 h; 3: di-tert-butyl dicarbonate in tetrahydrofuran T=60°C;
参考文献
SCHERING CORPORATION
Patent: US2005/197301 A1, 2005 ;
Location in patent: Page/Page column 123 ;
反应条件
1: di-tert-butyl dicarbonate With molybdenium(VI) dioxodichloride in dichloromethane T=20°C; 0.5 h; 2: (S)-2-amino-3,3-dimethyl-1-butanol in dichloromethane T=20°C; 12 h;
参考文献
Chen, Chien-Tien; Kuo, Jen-Huang; Pawar, Vijay D.; Munot, Yogesh S.; Weng, Shieu-Shien; Ku, Cheng-Hsiu; Liu, Cheng-Yuan
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1188 - 1197
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Addition; reduction;
参考文献
Busacca, Carl A.; Grossbach, Danja; Spinelli, Earl
Tetrahedron Asymmetry, 2000 , vol. 11, # 9 p. 1907 - 1910
反应条件
lithium borohydride in tetrahydrofuran; ethanol Ambient temperature;
参考文献
Braghiroli, Daniela; Di Bella, Maria
Tetrahedron Asymmetry, 1996 , vol. 7, # 7 p. 2145 - 2150
反应条件
1: (S)-2-amino-3,3-dimethyl-1-butanol With triethylamine in dichloromethane T=20°C; 0.5 h; Inert atmosphere; 2: carbonic acid di-tert-butyl ester in dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 75, # 3 p. 937 - 940
反应条件
1: NEt3 / tetrahydrofuran / -10 °C 2: NaBH4 / H2O / 0 °C View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 14, # 1 p. 275 - 278
反应条件
1: Et3N; DMAP / CH2Cl2 / 2 h / 20 °C 2: NaBH4 View Scheme
参考文献
Organic letters, , vol. 3, # 6 p. 897 - 899
反应条件
1: aq. NaOH / dioxane / 20 °C 2: NEt3 / tetrahydrofuran / -10 °C 3: NaBH4 / H2O / 0 °C View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 14, # 1 p. 275 - 278
反应条件
sodium tetrahydroborate
参考文献
Organic letters, , vol. 3, # 6 p. 897 - 899
反应条件
sodium tetrahydroborate in dichloromethane
参考文献
Journal of the American Chemical Society, , vol. 135, # 42 p. 15742 - 15745
