copper(l) iodide; sodium hydride in N,N-dimethyl-formamide 1.) r.t., 10 min, 2.) 100 deg C, 5 h;

tetrakis(triphenylphosphine) palladium(0); caesium carbonate in tetrahydrofuran T=100°C; 1 h; Inert atmosphereMicrowave irradiation; stereoselective reaction;

1: 71 percent / NaH, CuI / dimethylformamide / 1.) r.t., 10 min, 2.) 100 deg C, 5 h 2: 20 percent / NaH / tetrahydrofuran / 1.) r.t., 10 min, 2.) 0 deg C, 1.5 h View Scheme

tetrakis(triphenylphosphine) palladium(0); caesium carbonate in tetrahydrofuran T=100°C; 1 h; Inert atmosphereMicrowave irradiation; optical yield given as percent de;