N-(2-(7-羟基萘-1-基)乙基)乙酰胺合成路线 （共 8 条）
反应条件
potassium carbonate in acetone 5 h; Reflux;
参考文献
SYMED LABS LIMITED; MOHAN RAO, Dodda; ANNA REDDY, Ambati
Patent: WO2014/64706 A1, 2014 ;
Location in patent: Page/Page column 71 ;
反应条件
1: With boron tribromide in dichloromethane
T=0°C; 2 h;
2: With water in dichloromethane
T=0°C;
参考文献
Ettaoussi, Mohamed; Sabaouni, Ahmed; Rami, Marouan; Boutin, Jean A.; Delagrange, Philippe; Renard, Pierre; Spedding, Michael; Caignard, Daniel-Henri; Berthelot, Pascal; Yous, Said
European Journal of Medicinal Chemistry, 2012 , vol. 49, p. 310 - 323
反应条件
1: With sodium acetate in methanol
T=65 - 68°C;
2: With sodium hydroxide in methanol
Reflux;
参考文献
SYMED LABS LIMITED; MOHAN RAO, Dodda; ANNA REDDY, Ambati
Patent: WO2014/64706 A1, 2014 ;
Location in patent: Page/Page column 71 ;
反应条件
palladium on activated charcoal in toluene
20 h; Reflux;
参考文献
SYMED LABS LIMITED; MOHAN RAO, Dodda; ANNA REDDY, Ambati
Patent: WO2014/64706 A1, 2014 ;
Location in patent: Page/Page column 76 ;
反应条件
1: 80 percent / 47percent HBr / 7 h / Heating
2: 40 percent / K2CO3 / H2O; ethyl acetate
View Scheme
参考文献
Depreux; Lesieur; Mansour; Morgan; Howell; Renard; Caignard; Pfeiffer; Delagrange; Guardiola; Yous; Demarque; Adam; Andrieux
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3231 - 3239
反应条件
potassium carbonate in water; ethyl acetate
参考文献
Depreux; Lesieur; Mansour; Morgan; Howell; Renard; Caignard; Pfeiffer; Delagrange; Guardiola; Yous; Demarque; Adam; Andrieux
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3231 - 3239
反应条件
1.1: 4-hydroxy-benzoic acid; benzylamine / toluene / 6 h / 108 - 110 °C
2.1: ammonia; hydrogen / methanol / 40 - 45 °C / 0.38 Torr / |Autoclave
3.1: hydrogenchloride / ethyl acetate; isopropyl alcohol; hexane / 0.5 h / 0 - 15 °C / pH < 2
4.1: sulfur / 185 - 190 °C
5.1: sodium acetate / methanol / 65 - 68 °C
5.2: |Reflux
View Scheme
参考文献
SYMED LABS LIMITED; MOHAN RAO, Dodda; ANNA REDDY, Ambati
Patent: WO2014/64706 A1, 2014 ;
反应条件
human liver cytochrome P450 in methanol; acetate buffer
T=37°C; pH=8; Enzyme kinetics; Further Variations:Reagents;
参考文献
Bogaards, Jan J.P.; Hissink, Erna M.; Briggs, Mike; Weaver, Richard; Jochemsen, Roeline; Jackson, Peter; Bertrand, Marc; Van Bladeren, Peter J.
European Journal of Pharmaceutical Sciences, 2000 , vol. 12, # 2 p. 117 - 124
