1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine

1: N-tert-butoxycarbonyl-L-phenylalanine With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide T=0°C; Inert atmosphere; 2: methyl (2R)-2-(t-butoxycarbonylamino)-3-phenylpropionate With 4-methyl-morpholine in N,N-dimethyl-formamide T=20°C; Inert atmosphere;

1: pyridine / dichloromethane / 1 h / 20 °C 2: dichloromethane / 20 °C View Scheme

in dichloromethane T=20°C;