N,N'-二-Boc-1H-1-胍基吡唑合成路线 （共 8 条）
反应条件
1: tert-butyl (1H-pyrazol-1-ylcarbonoimidoyl)carbamate With sodium hydride in tetrahydrofuran T=-5 - 0°C; 1.5 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=-5 - 0°C; 2 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2008/126943 A2, ;
Page/Page column 79-80 ;
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; 2.66667 h; Product distribution / selectivity;
参考文献
WO2008/126943 A2, ;
Page/Page column 78-79 ;
反应条件
lithium hydride in tetrahydrofuran 8 h; Heating;
参考文献
Synthesis, , # 6 p. 579 - 582
反应条件
lithium hydride in tetrahydrofuran
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 20 p. 5905 - 5908
反应条件
1: 95 percent / DIEA / dimethylformamide / 0.67 h / Ambient temperature 2: 1.) NaH / 1.) THF, 0 deg C, 5 min, 2.) THF, 67 deg C, 4 h View Scheme
参考文献
Synthetic Communications, , vol. 23, # 21 p. 3055 - 3060
反应条件
1.1: CuCO3*Cu(OH)2 / H2O / Heating 1.2: N-ethyldiisopropylamine / formamide / 20 °C 2.1: 84 percent / aq. NaHCO3; ethylenediaminetetraacetic acid / acetone / 20 °C View Scheme
参考文献
Schaschke, Norbert
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 4 p. 855 - 857
反应条件
in N,N-dimethyl-formamide T=20°C; 17 h;
参考文献
TARGEGEN INC.
Patent: WO2009/55674 A1, 2009 ;
Location in patent: Page/Page column 74 ;
WO 2009/055674 A1
反应条件
Yield given. Multistep reaction;
参考文献
Robinson, Shaughnessy; Roskamp, Eric J.
Tetrahedron, 1997 , vol. 53, # 19 p. 6697 - 6705
