(2R,3S,5R)-5-[2-氟-6-(2-三甲基硅烷基乙氧基)嘌呤-9-基]-2-(羟基甲基)四氢呋喃-3-醇合成路线 （共 3 条）
反应条件
1: With N-ethyl-N,N-diisopropylamine in dimethyl sulfoxide T=55°C; 7 h; 2: With acetic acid T=20°C; 1 h;
参考文献
Nechev; Kozekov; Harris
Chemical Research in Toxicology, 2001 , vol. 14, # 11 p. 1506 - 1512
反应条件
1: 80 percent / triethylamine; dimethylsulfoxide / 6 h / 55 °C 2: acetic acid / 1 h / 20 °C View Scheme
参考文献
Wang, Mingyao; McIntee, Edward J.; Shi, Yongli; Cheng, Guang; Upadhyaya, Pramod; Villalta, Peter W.; Hecht, Stephen S.
Chemical Research in Toxicology, 2001 , vol. 14, # 10 p. 1428 - 1434
反应条件
1.1: diisopropylethylamine / dimethylsulfoxide / 7 h / 55 °C
1.2: 78 percent / acetic acid / 1 h / 20 °C
2.1: 88 percent / NaIO4; phosphate buffer / 0.17 h / 20 °C / pH 7
View Scheme
参考文献
Nechev; Kozekov; Harris
Chemical Research in Toxicology, 2001 , vol. 14, # 11 p. 1506 - 1512
