4-[2-(二甲胺基)乙氧基]苯甲醛合成路线 （共 12 条）
反应条件
1: 2-dimethylamino-1-chloro-ethane hydrochloride With sodium hydroxide in water; toluene 2: 4-hydroxy-benzaldehyde With tetrabutylammomium bromide; potassium carbonate in ethyl acetate; toluene 5 h; Heating / reflux;
参考文献
ERREGIERRE S.p.A.
Patent: WO2006/51079 A1, 2006 ;
Location in patent: Page/Page column 5 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 72 h;
参考文献
Strohfeldt, Katja; Mueller-Bunz, Helge; Pampillon, Clara; Sweeney, Nigel J.; Tacke, Matthias
European Journal of Inorganic Chemistry, 2006 , # 22 p. 4621 - 4628
反应条件
in methanol; water T=20°C; 60 h;
参考文献
Nagarapu, Lingaiah; Aneesa; Satyender, Apuri; Chandana; Bantu, Rajaskaker
Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 2 p. 195 - 200
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) 4 h; Heating / reflux;
参考文献
L. MOLTENI and C. DEI FRATELLI ALITTI SOCIETA DI ESERCIZIO S.P.A
Patent: WO2004/35590 A2, 2004 ;
Location in patent: Page 20 ;
反应条件
18-crown-6 ether; potassium carbonate in acetone 24 h; Heating;
参考文献
Journal of the American Chemical Society, , vol. 128, # 16 p. 5488 - 5495
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C 2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 1 p. 112 - 116
反应条件
1: ammonia / methanol / 8 h / 50 - 55 °C / 6000.6 - 7500.75 Torr / |Large scale 2: potassium carbonate / ethyl acetate / 2.5 h / 10 °C / |Inert atmosphere; |Large scale 3: hydrogenchloride / acetone; water / |Large scale View Scheme
参考文献
Neelakandan; Manikandan; Santosha; Prabhakaran
Organic Process Research and Development, 2013 , vol. 17, # 7 p. 981 - 984
反应条件
ammonium acetate; 1-nitroethane in acetic acid 4 h; Heating;
参考文献
Kmonicek, Vojtech; Vejdelek, Zdenek; Holubek, Jiri; Valchar, Martin; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 6 p. 1721 - 1733
反应条件
1: With hydroxylamine hydrochloride in water; acetic acid T=0 - 5°C; 2 h; 2: With acetic acid; zinc in water T=45 - 70°C; 7 h;
参考文献
WO2006/51079 A1, ;
Page/Page column 5-6 ;
反应条件
1: Raney nickel; ethanol; NH3 / 80 °C / 51485.6 Torr / Hydrogenation View Scheme
