双环[2.2.2]锌-2-烯-2,3-二羧酸酐合成路线 （共 7 条）
反应条件
1.1: tetrahydrofuran / 18 h / 60 °C 2.1: palladium on activated charcoal; hydrogen / ethyl acetate / 2 h 3.1: sodium hydroxide; water / methanol / 8 h / 60 °C 3.2: pH 1 4.1: acetic anhydride / 1.5 h / 100 °C View Scheme
反应条件
1.1: palladium on activated charcoal; hydrogen / ethyl acetate / 2 h 2.1: sodium hydroxide; water / methanol / 8 h / 60 °C 2.2: pH 1 3.1: acetic anhydride / 1.5 h / 100 °C View Scheme
反应条件
1.1: sodium hydroxide; water / methanol / 8 h / 60 °C 1.2: pH 1 2.1: acetic anhydride / 1.5 h / 100 °C View Scheme
反应条件
Hydrieren an Palladium in Aceton, Erwaermen mit aethanol. Kalilauge und mit Acetylchlorid;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 490, p. 257,263
参考文献
Justus Liebigs Annalen der Chemie, , vol. 478, p. 137,149
Justus Liebigs Annalen der Chemie, , vol. 490, p. 236,241
反应条件
1: hydrazine hydrate; acetic acid; sodium acetate / 16 h / 100 °C 2: trichlorophosphate / 5 h / 110 °C View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; TAN, Yumei; LUO, Huichao
Patent: WO2014/19344 A1, 2014 ;
