(S)-(+)-1-苯基-2-丙醇合成路线 （共 70 条）
反应条件
1: 57 percent / K2CO3 / acetone / 48 h 2: 95 percent / H2 / 10percent Pd/C / ethanol / 48 h View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 7, # 11 p. 3129 - 3134
反应条件
1: With (R)-2-tert-butyl-quinazolinap rhodium; benzo[1,3,2]dioxaborole in tetrahydrofuran T=20°C; 2 h; 2: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran; ethanol T=0 - 20°C; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 69, # 20 p. 6572 - 6589
反应条件
1: With vinyl acetate; immobilized Novozym 435(R) Candida antarctica lipase-B in hexane T=32°C; 72 h; 2: With triphenylstannane; 1,1'-azobis (cyclohexanecarbonitrile) in hexane; toluene 4 h; Heating; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 15, # 24 p. 3945 - 3954
反应条件
1.1: 16 percent / potassium carbonate; N-chlorosuccinimide / CH2Cl2 / 140 h / 20 °C 2.1: EtMgCl / toluene; tetrahydrofuran / 0.8 h / -78 °C 2.2: toluene; tetrahydrofuran / Heating 2.3: 56 percent / sodium hydroxide; hydrogen peroxide / various solvents / 3 h / 0 - 20 °C View Scheme
参考文献
Organic Letters, , vol. 8, # 4 p. 773 - 776
反应条件
Candida antarctica lipase B immobilized on acrylic resin in tetrahydrofuran; hexane T=25°C; P=750.075 Torr; Title compound not separated from byproducts.;
参考文献
Tetrahedron Asymmetry, , vol. 19, # 2 p. 237 - 246
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=20°C; Inert atmosphere; 2: With immobilized Candida antarctica Lipase B; water in hexane T=30°C; pH=6.5; 24 h; aq. phosphate bufferEnzymatic reaction; 3: With water; sodium hydroxide in methanol T=20°C; 1 h; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron, , vol. 66, # 40 p. 8060 - 8067
反应条件
1: methylmagnesium bromide With titanium(IV) isopropylate; (Sa)-2'-[(R)-hydroxy(phenyl)methyl]-(1,1'-binaphthalen)-2-ol in toluene T=-20°C; 0.166667 h; Inert atmosphere; 2: phenylacetaldehyde in toluene T=-40°C; Grignard reaction; 4 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
European Journal of Organic Chemistry, , # 34 p. 6851 - 6855
反应条件
1: With (Sa)-2'-[(R)-hydroxy(phenyl)methyl]-(1,1'-binaphthalen)-2-ol; titanium (IV) isopropoxide in toluene T=-40°C; 1 h; Inert atmosphere; 2: With hydrogenchloride in water Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
European Journal of Organic Chemistry, , # 20 p. 3732 - 3736
反应条件
Pseudomonas cepacia lipase; 4 A molecular sieve; peracetylated-β-cyclodextrin in toluene T=40°C; 2 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 14, # 17 p. 2547 - 2555
反应条件
1: 91 percent / D-glucose, fresh baker's yeast, XAD1180 resin / H2O / 48 h / 25 °C 2: 73 percent / aq. NaOH / 0.75 h / 65 °C 3: 86 percent / LiAlH4 / diethyl ether / 2 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 9, # 22 p. 4021 - 4026
