2-氯-2,2-二氟乙酸甲酯合成路线

1514-87-02-氯-2,2-二氟乙酸甲酯→1184-76-5二碘二氟甲烷+74-88-4甲基碘

参考文献

Su; Duan; Chen
Journal of the Chemical Society - Series Chemical Communications, 1992 , # 11 p. 807 - 808

1514-87-02-氯-2,2-二氟乙酸甲酯→2314-97-8三氟碘甲烷+124-38-9二氧化碳+1184-76-5二碘二氟甲烷+74-88-4甲基碘

参考文献

Journal of the Chemical Society - Series Chemical Communications, , # 11 p. 807 - 808

1514-87-02-氯-2,2-二氟乙酸甲酯+139-85-5原儿茶醛→127842-54-03,4-双(二氟甲氧基)苯甲醛+151103-08-14-二氟甲氧基-3-羟基苯甲醛

参考文献

Journal of Medicinal Chemistry, , vol. 51, # 24 p. 7673 - 7688

1514-87-02-氯-2,2-二氟乙酸甲酯+139-85-5原儿茶醛→151103-08-14-二氟甲氧基-3-羟基苯甲醛

参考文献

SmithKline Beecham Corporation
Patent: US5731477 A1, 1998 ;

1514-87-02-氯-2,2-二氟乙酸甲酯+365413-29-26-氯-5-碘烟酸甲酯→1360952-35-76-氯-5-(三氟甲基)-3-吡啶羧酸甲酯

参考文献

Mulder, Jason A.; Frutos, Rogelio P.; Patel, Nitinchandra D.; Qu, Bo; Sun, Xiufeng; Tampone, Thomas G.; Gao, Joe; Sarvestani, Max; Eriksson, Magnus C.; Haddad, Nizar; Shen, Sherry; Song, Jinhua J.; Senanayake, Chris H.
Organic Process Research and Development, 2013 , vol. 17, # 6 p. 940 - 945

1514-87-02-氯-2,2-二氟乙酸甲酯+365413-29-26-氯-5-碘烟酸甲酯→73781-91-66-氯烟酸甲酯+1360952-35-76-氯-5-(三氟甲基)-3-吡啶羧酸甲酯

参考文献

Mulder, Jason A.; Frutos, Rogelio P.; Patel, Nitinchandra D.; Qu, Bo; Sun, Xiufeng; Tampone, Thomas G.; Gao, Joe; Sarvestani, Max; Eriksson, Magnus C.; Haddad, Nizar; Shen, Sherry; Song, Jinhua J.; Senanayake, Chris H.
Organic Process Research and Development, 2013 , vol. 17, # 6 p. 940 - 945

1514-87-02-氯-2,2-二氟乙酸甲酯+1122-74-34-碘-2-甲基磺酰基嘧啶→136547-20-14-三氟甲基-2-甲基硫代嘧啶

参考文献

Ple, N.; Turck, A.; Heynderickx, A.; Queguiner, G.
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 2 p. 551 - 556

1514-87-02-氯-2,2-二氟乙酸甲酯+106-95-63-溴丙烯→1524-26-11,1,1-三氟丁烯-3+2317-84-2+129846-67-9+135671-20-4

参考文献

Su, De-Bao; Duan, Jian-Xing; Yu, An-Juan; Chen, Qing-Yun
Journal of Fluorine Chemistry, 1993 , vol. 65, # 1-2 p. 11 - 14

1514-87-02-氯-2,2-二氟乙酸甲酯+121-33-5香草醛→162401-70-94-二氟甲氧基-3-甲氧基苯甲醛

参考文献

Williams, Spencer J.; Zammit, Steven C.; Cox, Alison J.; Shackleford, David M.; Morizzi, Julia; Zhang, Yuan; Powell, Andrew K.; Gilbert, Richard E.; Krum, Henry; Kelly, Darren J.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6868 - 6873

1514-87-02-氯-2,2-二氟乙酸甲酯+135034-10-53-氯-6-碘哒嗪→258506-68-23-氯-6-三氟甲基哒嗪

参考文献

Goodman, Allan J.; Stanforth, Stephen P.; Tarbit, Brian
Tetrahedron, 1999 , vol. 55, # 52 p. 15067 - 15070