2-溴-3,3,3-三氟丙烯合成路线 （共 51 条）
反应条件
1: 2-Bromo-3,3,3-trifluoro-propene With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 0.0833333 h; 2: benzaldehyde in tetrahydrofuran; hexane T=-78°C; 0.5 h; 3: With triethylamine in tetrahydrofuran 16 h; Reflux;
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 44 p. 11642 - 11646
Angew. Chem., , vol. 125, # 44 p. 11856 - 11860,5
反应条件
bis-triphenylphosphine-palladium(II) chloride; water; triethylamine in tetrahydrofuran T=75 - 80°C; P=26600 Torr; 2 h;
参考文献
Fuchikami; Yamanouchi; Ojima
Synthesis, 1984 , vol. NO. 9, p. 766 - 768
反应条件
(i) nBuLi, (ii) /BRN= 1900390/; Multistep reaction;
参考文献
Kitazume,T.; Ishikawa,N.
Journal of Fluorine Chemistry, 1985 , vol. 29, p. 431
反应条件
calcium hydroxide powder; dimethyl sulfate; dicobalt octacarbonyl T=25°C; P=760 Torr; Yield given. Yields of byproduct given;
参考文献
Botteghi, Carlo; Lando, Claudia; Matteoli, Ugo; Paganelli, Stefano; Menchi, Gloria
Journal of Fluorine Chemistry, 1997 , vol. 83, # 1 p. 67 - 71
反应条件
(i) nBuLi, (ii) /BRN= 505984/; Multistep reaction;
参考文献
Drakesmith,F.G. et al.
Journal of Organic Chemistry, 1968 , vol. 33, # 1 p. 280 - 285
反应条件
bis-triphenylphosphine-palladium(II) chloride; triphenyl-arsane; potassium hydroxide in tetrahydrofuran; ethylene glycol dimethyl ether; water T=74°C; Suzuki coupling; 12 h; Inert atmosphereSealed tube;
参考文献
Walkowiak, Justyna; Del Campo, Teresa Martinez; Ameduri, Bruno; Gouverneur, Veronique
Synthesis, 2010 , # 11 art. no. C02810SS, p. 1883 - 1890
反应条件
NiCl2((PPh3)P)2 in tetrahydrofuran T=50°C; 0.5 h;
参考文献
Kobayashi, Osamu; Uraguchi, Daisuke; Yamakawa, Tetsu
Journal of Fluorine Chemistry, 2009 , vol. 130, # 6 p. 591 - 594
反应条件
chloro-trimethyl-silane; N,N,N',N,-tetramethylethylenediamine; silver; zinc in tetrahydrofuran multistep reaction; other aryl halides;
参考文献
Jiang, Biao; Xu, Yuanyao
Journal of Organic Chemistry, 1991 , vol. 56, # 26 p. 7336 - 7340
反应条件
lithium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran T=100°C; P=7500.75 Torr; 15 h; Product distribution / selectivity;
参考文献
Tosoh F-Tech, Inc.; SAGAMI CHEMICAL RESEARCH CENTER
Patent: EP1637514 A1, 2006 ;
Location in patent: Page/Page column 22; 23 ;
反应条件
lithium diisopropyl amide 1.) THF, -78 deg C, 5 min, 2.) 30 min; Yield given. Multistep reaction;
参考文献
Xiao, Ling; Yamazaki, Takashi; Kitazume, Tomoya; Yonezawa, Tetsuo; Sakamoto, Yoshitake; Nogawa, Kouji
Journal of Fluorine Chemistry, 1997 , vol. 84, # 1 p. 19 - 23
