反应条件
1.1: sodium methylate / methanol / 0.5 h / 20 °C
1.2: 2 h / 0 °C
2.1: potassium carbonate / acetone / 8 h / |Reflux
3.1: acetic acid; iron / 1.5 h / 90 °C
4.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; 1,4-dioxane / 24 h / |Reflux
5.1: ozone / dichloromethane; methanol / -71 °C
View Scheme
参考文献
Singh, Sheo B.; Kaelin, David E.; Wu, Jin; Miesel, Lynn; Tan, Christopher M.; Meinke, Peter T.; Olsen, David; Lagrutta, Armando; Bradley, Prudence; Lu, Jun; Patel, Sangita; Rickert, Keith W.; Smith, Robert F.; Soisson, Stephen; Wei, Changqing; Fukuda, Hideyuki; Kishii, Ryuta; Takei, Masaya; Fukuda, Yasumichi
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 5 p. 609 - 614