N-Boc-(S)-(-)-2-氨基-1-丁醇合成路线 （共 7 条）
反应条件
in dichloromethane T=0°C;
参考文献
Hoffmann-La Roche Inc.; Banner, David; Haap, Wolfgang; Kuhn, Bernd; Luebbers, Thomas; Peters, Jens-Uwe; Schulz-Gasch, Tanja
Patent: US2013/137687 A1, 2013 ;
Location in patent: Paragraph 0177 ;
反应条件
sodium hydroxide in 1,4-dioxane; water T=0 - 20°C; 2 h;
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2004/838 A1, 2003 ;
Location in patent: Page 73 ;
WO 2004/000838 A1
反应条件
hydrogen; {(1,5-cyclooctadiene)Rh(1,2-bis((2S,5S)-2,5-diethylphospholano)benzene)}triflate in tetrahydrofuran T=20 - 25°C; Catalytic hydrogenation; P=1551.44 Torr; 12 h; Title compound not separated from byproducts;
参考文献
Burk, Mark J.; Johnson, Nicholas B.; Lee, Jeffrey R.
Tetrahedron Letters, 1999 , vol. 40, # 36 p. 6685 - 6688
反应条件
dimethylsulfide borane complex
参考文献
Banfi, Luca; Guanti, Giuseppe; Riva, Renata; Basso, Andrea; Calcagno, Emiliano
Tetrahedron Letters, 2002 , vol. 43, # 22 p. 4067 - 4069
反应条件
1: LiAlH4 / tetrahydrofuran 2: H2 / (S,S)-[(Et-DuPHOS)Rh(COD)]OTf / tetrahydrofuran / 12 h / 20 - 25 °C / 1551.44 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 36 p. 6685 - 6688
反应条件
1: base 2: LiAlH4 / tetrahydrofuran 3: H2 / (S,S)-[(Et-DuPHOS)Rh(COD)]OTf / tetrahydrofuran / 12 h / 20 - 25 °C / 1551.44 Torr View Scheme
参考文献
Burk, Mark J.; Johnson, Nicholas B.; Lee, Jeffrey R.
Tetrahedron Letters, 1999 , vol. 40, # 36 p. 6685 - 6688
反应条件
1: aq. NaOH / dioxane / 20 °C 2: NEt3 / tetrahydrofuran / -10 °C 3: NaBH4 / H2O / 0 °C View Scheme
参考文献
Catalano, John G; Deaton, David N; Furfine, Eric S; Hassell, Annie M; McFadyen, Robert B; Miller, Aaron B; Miller, Larry R; Shewchuk, Lisa M; Willard Jr., Derril H; Wright, Lois L
Bioorganic and medicinal chemistry letters, 2004 , vol. 14, # 1 p. 275 - 278
