(S)-2,3-二甲基丁酸合成路线 （共 11 条）
反应条件
C32H12BF24(1-)*C54H71IrNP(1+); hydrogen; caesium carbonate in methanol T=45°C; 4 h; optical yield given as percent eeenantioselective reaction;
参考文献
Zhu, Shou-Fei; Yu, Yan-Bo; Li, Shen; Wang, Li-Xin; Zhou, Qi-Lin
Angewandte Chemie - International Edition, 2012 , vol. 51, # 35 p. 8872 - 8875
反应条件
hydrogen; lt;RuI((R)-2,2'-bis(diphenylphosphino)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl)(p-cymene)gt;I in tetrahydrofuran P=76000 Torr; 44 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 61, # 16 p. 5510 - 5516
反应条件
dihydrogen peroxide; lithium hydroxide hydrate in tetrahydrofuran; water T=23°C; 6 h;
参考文献
Ohtaka, Junpei; Hamajima, Akinari; Nemoto, Tetsuhiro; Hamada, Yasumasa
Chemical and Pharmaceutical Bulletin, 2013 , vol. 61, # 2 p. 245 - 250
反应条件
1: With ozone in acetone T=-78°C; 2: With jones reagent in acetone T=0°C; Jones oxidation; 0.25 h; Further stages.;
参考文献
Organic Letters, , vol. 9, # 6 p. 1041 - 1044
反应条件
1: 610.0 mg / KOH / ethanol; H2O / 4 h / Heating 2: H2 / Ru(OCOCH3)2<(S)-2,2'-bis(diphenylphosphino)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl> / tetrahydrofuran / 3 h / 76000 Torr / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 16 p. 5510 - 5516
反应条件
sodium periodate; RuCl3 monohydrate; water in tetrachloromethane; acetonitrile T=20°C; 15 h; Inert atmosphere;
参考文献
Tetrahedron Asymmetry, , vol. 20, # 11 p. 1224 - 1234
反应条件
1: 1.) MeLi / tetrahydrofuran; diethyl ether / 1.) -78 deg C, 30 min, 2.) -78 deg C, 20 min. 2: tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) r.t., 30 min 3: 30percent H2O2 / 1 h View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 14 p. 1673 - 1682
反应条件
1: tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) r.t., 30 min 2: 30percent H2O2 / 1 h View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 14 p. 1673 - 1682
参考文献
Gazzetta Chimica Italiana, , vol. 89, p. 1627,1631
反应条件
Jone's reagent; ozone
参考文献
Journal of the American Chemical Society, , vol. 133, # 23 p. 9119 - 9123
