1-(2-羟基乙基)-3,7-二甲基黄嘌呤合成路线 （共 8 条）
反应条件
methanol; sodium tetrahydroborate in tert-butyl alcohol T=90°C; 1.25 h;
参考文献
Fischer, Bilha; Yefidoff, Revital; Major, Dan T.; Rutman-Halili, Irit; Shneyvays, Valadimir; Zinman, Tova; Jacobson, Kenneth A.; Shainberg, Asher
Journal of Medicinal Chemistry, 1999 , vol. 42, # 14 p. 2685 - 2696
反应条件
1: 3,7-dimethyl xanthine With potassium carbonate in N,N-dimethyl-formamide Reflux; 2: 2-hydroxy-1-iodoethane 18 h; Reflux;
参考文献
Panzner, Matthew J.; Hindi, Khadijah M.; Wright, Brian D.; Taylor, Jane B.; Han, Daniel S.; Youngs, Wiley J.; Cannon, Carolyn L.
Dalton Transactions, 2009 , # 35 p. 7308 - 7313
反应条件
1: dimethylformamide / 4.5 h / 110 °C 2: 57 percent / NaBH4, MeOH / 2-methyl-propan-2-ol / 1.25 h / 90 °C View Scheme
参考文献
Fischer, Bilha; Yefidoff, Revital; Major, Dan T.; Rutman-Halili, Irit; Shneyvays, Valadimir; Zinman, Tova; Jacobson, Kenneth A.; Shainberg, Asher
Journal of Medicinal Chemistry, 1999 , vol. 42, # 14 p. 2685 - 2696
反应条件
sodium hydroxide in isopropyl alcohol T=120°C; 24 h; Yield given;
参考文献
Madyastha; Sridhar
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 6 p. 677 - 680
反应条件
sodium hydroxide T=100 - 120°C;
参考文献
Bayer and Co.
Patent: DE191106 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 8, p. 1136
反应条件
pyridine; propan-1-ol
参考文献
Roth
Archiv der Pharmazie (Weinheim, Germany), 1959 , vol. 292, p. 234,236,237
反应条件
1: CHCl3; PCl5
View Scheme
参考文献
Rojahn; Fegeler
Archiv der Pharmazie (Weinheim, Germany), 1930 , vol. 268, p. 567,569
反应条件
chloroform; phosphorus pentachloride
参考文献
Rojahn; Fegeler
Archiv der Pharmazie (Weinheim, Germany), 1930 , vol. 268, p. 567,569
