5,6-O-异丙叉基-L-抗坏血酸合成路线 （共 32 条）
反应条件
1: 52 percent / 0.1 N aq. KOH / 18 h / 20 °C / nickel(III) oxide hydroxide, 0.15 A 2: N,N,N',N'-tetramethylethylenediamine / acetonitrile / 5 h / 50 °C View Scheme
参考文献
Ruholl, Heinrich; Schaefer, Hans J.
Synthesis, 1988 , # 1 p. 54 - 56
反应条件
1: 5,6-O-isopropylidene-L-ascorbic acid With sodium hydroxide; dihydrogen peroxide; sodium hydrogencarbonate in water T=20°C; 1 h; 2: dimethyl sulfate With sodium hydrogencarbonate; sodium sulfite in water T=40°C; 4 h;
参考文献
Cho, Bong Hwan; Kim, Jin Hwan; Jeon, Heung Bae; Kim, Kwan Soo
Tetrahedron, 2005 , vol. 61, # 18 p. 4341 - 4346
反应条件
1: H2O2; K2CO3 / H2O 2: 93 percent / acetonitrile / 82 °C View Scheme
参考文献
Abushanab; Bessodes; Antonakis
Tetrahedron Letters, 1984 , vol. 25, # 35 p. 3841 - 3844
反应条件
18-crown-6 ether; potassium tert-butylate 1.)1.) toluene, r.t., 2.) 72 h; Yield given. Multistep reaction;
参考文献
Frimer; Gilinsky-Sharon
Journal of Organic Chemistry, 1995 , vol. 60, # 9 p. 2796 - 2801
反应条件
18-crown-6 ether 1.) toluene, r.t., 2.) 72 h; Yield given. Multistep reaction;
参考文献
Frimer; Gilinsky-Sharon
Journal of Organic Chemistry, 1995 , vol. 60, # 9 p. 2796 - 2801
反应条件
1: K2CO3; TBAB / tetrahydrofuran / 30 °C 2: 10 percent / DBU / tetrahydrofuran / 12 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 47, # 13 p. 2219 - 2222
参考文献
Danielmeier, Karsten; Steckhan, Eberhard
Tetrahedron: Asymmetry, 1995 , vol. 6, # 5 p. 1181 - 1190
反应条件
1: LiAlH4 / tetrahydrofuran / 2 h / Heating 2: aq. NaIO4 / tetrahydrofuran / 2 h / 0 °C 3: NaBH4 / ethyl acetate; ethanol / 2.5 h / Ambient temperature 4: 80.3 percent / pyridine / Ambient temperature View Scheme
参考文献
Jung, Michael E.; Shaw, Teresa J.
Journal of the American Chemical Society, 1980 , vol. 102, # 20 p. 6304 - 6311
反应条件
1: 70 percent / sodium bicarbonate / dimethylsulfoxide / 16 h / 50 °C 2: 98 percent / 2M HCl / methanol / 3 h / 60 °C View Scheme
参考文献
Nihro, Yasunori; Sogawa, Satoshi; Izumi, Akihiro; Sasamori, Akihiro; Sudo, Tadamitsu; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 9 p. 1618 - 1623
反应条件
1: K2CO3 / dimethylformamide / Heating 2: aq. AcOH / methanol / 80 °C 3: pyridine; 4-dimethylaminopyridine / CH2Cl2 4: H2 / Pd/C / ethanol / 3000.24 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 20 p. 5313 - 5316
