1-溴-4-甲氧基-2-苯基甲氧基苯合成路线 （共 9 条）
反应条件
Ki; nitrogen in ethyl acetate
参考文献
SmithKline Beecham Corporation
Patent: US6143907 A1, 2000 ;
反应条件
[Ru(II)(2,2’-bipyridine)3]Cl2; carbon tetrabromide in acetonitrile T=20°C; Irradiation; Overall yield = 98 percent;
参考文献
Zhao, Yating; Li, Zhe; Yang, Chao; Lin, Run; Xia, Wujiong
Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 622 - 627
反应条件
potassium carbonate in acetone T=60°C; 12 h;
参考文献
Niiyama, Kenji; Yoshizumi, Takashi; Takahashi, Hirobumi; Naya, Akira; Ohtake, Norikazu; Fukami, Takehiro; Mase, Toshiaki; Hayama, Takashi; Ishikawa, Kiyofumi
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 11 p. 3437 - 3444
反应条件
1: methanol With potassium tert-butylate in N,N-dimethyl-formamide T=0°C; 0.166667 h; prs; 2: 2-benzyloxy-1-bromo-4-fluorobenzene in N,N-dimethyl-formamide T=80°C; 20 h; Further stages.;
参考文献
Dirr, Ronan; Anthaume, Cyril; Desaubry, Laurent
Tetrahedron Letters, 2008 , vol. 49, # 31 p. 4588 - 4590
反应条件
potassium carbonate in ethanol 16 h; Inert atmosphereReflux;
参考文献
Aikawa, Kohsuke; Miyazaki, Yoshitaka; Mikami, Koichi
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 2 p. 201 - 208
反应条件
1.1: potassium carbonate / acetone / 16 h / Inert atmosphere; Reflux 2.1: acetone / 16 h / Inert atmosphere; Reflux 3.1: sodium hydroxide / methanol / 12 h / Inert atmosphere; Reflux 3.2: pH 1 4.1: potassium carbonate / ethanol / 16 h / Inert atmosphere; Reflux View Scheme
参考文献
Aikawa, Kohsuke; Miyazaki, Yoshitaka; Mikami, Koichi
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 2 p. 201 - 208
反应条件
1.1: acetone / 16 h / Inert atmosphere; Reflux 2.1: sodium hydroxide / methanol / 12 h / Inert atmosphere; Reflux 2.2: pH 1 3.1: potassium carbonate / ethanol / 16 h / Inert atmosphere; Reflux View Scheme
参考文献
Aikawa, Kohsuke; Miyazaki, Yoshitaka; Mikami, Koichi
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 2 p. 201 - 208
反应条件
hydrogenchloride; magnesium in tetrahydrofuran; ethyl acetate
参考文献
SmithKline Beecham Corporation
Patent: US6143907 A1, 2000 ;
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.0833333 h; Inert atmosphere; 2: With boric acid trimethyl ester in tetrahydrofuran; diethyl ether; hexane T=-50°C; 0.5 h; Inert atmosphere; 3: With hydrogenchloride in tetrahydrofuran; diethyl ether; hexane; water T=20°C;
参考文献
Aikawa, Kohsuke; Miyazaki, Yoshitaka; Mikami, Koichi
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 2 p. 201 - 208
