N-苄氧羰酰基-2-甲基丙氨酸合成路线 （共 18 条）
反应条件
sodium carbonate in 1,4-dioxane; water T=20°C; 20 h;
参考文献
Lai, Michelle Y.H.; Brimble, Margaret A.; Callis, David J.; Harris, Paul W.R.; Levi, Mark S.; Sieg, Frank
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 533 - 548
反应条件
1: With sodium hydrogencarbonate in tetrahydrofuran; water T=0 - 20°C; 12 h; 2: With hydrogenchloride; water T=0°C; pH=2;
参考文献
Sunesis Pharmaceuticals, Inc.
Patent: US2009/36419 A1, 2009 ;
Location in patent: Page/Page column 93 ;
US 20090036419 A1
反应条件
1: 2-amino-2-methylpropionic acid With sodium carbonate in water 2: benzyl chloroformate in 1,4-dioxane; water T=0 - 20°C; 1.75 h;
参考文献
NEUREN PHARMACEUTICALS LIMITED; NEUREN PHARMACEUTICALS INC.
Patent: WO2006/127702 A2, 2006 ;
Location in patent: Page/Page column 70-71 ;
反应条件
diethyl ether anfangs unter Kuehlung, und Behandlung des Reaktionsprodukts mit wss.-aethanol. NaOH;
参考文献
Journal of Biological Chemistry, , vol. 109, p. 344
反应条件
sodium hydroxide; sodium carbonate anschliessend Behandeln mit Chlorokohlensaeure-benzylester;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 43, p. 3873,3881
参考文献
Valle, Giovanni; Formaggio, Fernando; Crisma, Marco; Bonora, Gian Maria; Toniolo, Claudio; et al.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1986 , p. 1371 - 1376
反应条件
1: 1.)ClCOOEt/Et3N 2.)NH3(g)/THF / 1.)-8 deg C, 10 min 2.)r.t., 3 h 2: 2N aq. NaOH / methanol / 1.5 h / Ambient temperature View Scheme
参考文献
Zanotti; Pinnen
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 8 p. 1629 - 1633
反应条件
1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / -15 °C 1.2: 11 h / -15 - 60 °C 2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 10 h / 0 - 20 °C / Inert atmosphere 3.1: hydroxylamine hydrochloride; potassium hydroxide / water; isopropyl alcohol / 60 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 50, p. 361 - 369
反应条件
1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / -15 °C 1.2: 11 h / -15 - 60 °C 2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 10 h / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Wang, Ziwen; Wang, Mingxiao; Yao, Xue; Li, Yue; Qiao, Wentao; Geng, Yunqi; Liu, Yuxiu; Wang, Qingmin
European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 361 - 369
反应条件
1: With pyridine; di-tert-butyl dicarbonate; (NH4)2CO3 T=20°C; 3 h; 2: With 5 palladium on charcoal; hydrogen in methanol 3.5 h;
参考文献
TAISHO PHARMACEUTICAL CO., LTD; Kakinuma, Hiroyuki; Kobashi, Yohei; Chonan, Tomomichi; Shiozawa, Fumiyasu; Iwata, Yuki; Oi, Takahiro; Kawabe, Kenichi
Patent: US2013/165645 A1, 2013 ;
Location in patent: Paragraph 0159; 0160; 0161 ;
