2-乙酰氧基-5-溴苯甲酸合成路线 （共 7 条）
参考文献
Sharma, Horrick; Patil, Shivaputra; Sanchez, Tino W.; Neamati, Nouri; Schinazi, Raymond F.; Buolamwini, John K.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 6 p. 2030 - 2045
反应条件
sodium chloride; sulfuric acid; acetic anhydride in water; ethyl acetate
参考文献
Kowa Co., Ltd.
Patent: US6136848 A1, 2000 ;
反应条件
pyridine in dichloromethane
参考文献
TRANSTECH PHARMA, INC.
Patent: WO2004/14844 A2, 2004 ;
Location in patent: Page 203 ;
WO 2004/014844 A2
反应条件
1.1: SOCl2; urea / toluene / 3 h / 100 - 110 °C 2.1: Mg; EtOH / CCl4; toluene / 1 h / Heating 2.2: CCl4; toluene / 0.5 h / 20 °C 3.1: p-TsOH / H2O / 3 h / Heating 4.1: 88 percent / 3 N HCl / ethanol / 3 h / Heating View Scheme
参考文献
Jung; Min; Park
Synthetic Communications, 2001 , vol. 31, # 12 p. 1837 - 1845
反应条件
1: oxalyl chloride / dimethylformamide; tetrahydrofuran / 1 h / Ambient temperature 2: conc. aq. NH3 / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Yamamoto, Satoshi; Hashiguchi, Shohei; Miki, Shokyo; Igata, Yumiko; Watanabe, Toshifumi; Shiraishi, Mitsuru
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 4 p. 734 - 745
反应条件
1: oxalyl chloride / dimethylformamide; tetrahydrofuran / 1 h / Ambient temperature 2: conc. aq. NH3 / tetrahydrofuran / 2 h / Ambient temperature View Scheme
参考文献
Yamamoto, Satoshi; Hashiguchi, Shohei; Miki, Shokyo; Igata, Yumiko; Watanabe, Toshifumi; Shiraishi, Mitsuru
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 4 p. 734 - 745
反应条件
phosphorus pentachloride in benzene
1 h; Heating;
参考文献
Bevan, Peter S.; Ellis, Gwynn P.; Hudson, Henrietta V.; Romney-Alexander, Trevor M.; Williams, J. Michael
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1643 - 1650
