4-羟基-N,N-二甲基苯磺酰胺合成路线 （共 10 条）
反应条件
1: 55 percent / conc. HNO3, conc. H2SO4 / -20 °C 2: 68 percent / H2 / 5percent Pd/C / ethanol View Scheme
参考文献
Ford; Knowles; Lunt; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 4 p. 538 - 549
反应条件
dimethyl amine in thionyl chloride
参考文献
Imperial Chemical Industries PLC
Patent: US5270311 A1, 1993 ;
反应条件
aluminium trichloride in benzene
参考文献
Fujisawa Pharmaceutical Company, Ltd.
Patent: US5104890 A1, 1992 ;
反应条件
triethylamine in chloroform
T=20°C; 10 h;
参考文献
Levin, Jeremy I.; Du, Mila T.; Park, Kaapjoo
Synthetic Communications, 2004 , vol. 34, # 15 p. 2773 - 2781
反应条件
1-hydroxybut-2-yne; potassium tert-butylate in dimethyl sulfoxide
T=125°C; 0.25 h; Microwave irradiation;
参考文献
Mittapalli, Gopi Kumar; Vellucci, Danielle; Yang, Jun; Toussaint, Marion; Brothers, Shaun P.; Wahlestedt, Claes; Roberts, Edward
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 3916 - 3920
反应条件
aluminium trichloride
T=90°C; Fries reaarangement; 0.0833333 h;
参考文献
Benson; Maughan, Patrick J; Shelly, Declan P; Spillane, William J
Tetrahedron Letters, 2001 , vol. 42, # 49 p. 8729 - 8731
反应条件
1: CHCl3 / 1 h / 20 °C
2: triethylamine / CHCl3 / 10 h / 20 °C
3: methanol / CHCl3 / 1 h / 65 °C
View Scheme
参考文献
Levin, Jeremy I.; Du, Mila T.; Park, Kaapjoo
Synthetic Communications, 2004 , vol. 34, # 15 p. 2773 - 2781
参考文献
Eliel; Nelson
Journal of Organic Chemistry, 1955 , vol. 20, p. 1657,1661
反应条件
ethanol
T=50 - 60°C;
参考文献
Steinkopf
Journal fuer Praktische Chemie (Leipzig), 1927 , vol. <2> 117, p. 21
参考文献
American Cyanamid Company
Patent: US3979203 A1, 1976 ;
