piperidine; 5-[(2S)-pyrrolidine-2-yl]-1H-tetrazole in chloroform T=20°C; Michael condensation; 72 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Wascholowski, Veit; Knudsen, Kristian Rahbek; Mitchell, Claire E. T.; Ley, Steven V.
Chemistry - A European Journal, 2008 , vol. 14, # 20 p. 6155 - 6165
hexafluoroisopropyl alcohol; (S)-N-(2-pyrrolidylmethyl)-N,N,N-trimethylammonium hydroxide in toluene amounts of chiral additive and 1,1,1,3,3,3-hexafluoro-2-propanol were varied; Product distribution;
1: piperidine; AcOH / toluene / 4 h / Heating 2: 70 percent / benzyl alcohol; Cs2CO3; dppp / [Ir(COD)Cl]2 / toluene / 24 h / 150 °C View Scheme
参考文献
Black, Phillip. J.; Cami-Kobeci, Gerta; Edwards, Michael G.; Slatford, Paul A.; Whittlesey, Michael K.; Williams, Jonathan M. J.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 1 p. 116 - 125
Ru(PPh3)3(CO)H2; piperidinium acetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in toluene 4 h; Reflux;
参考文献
Nixon, Tracy D.; Slatford, Paul A.; Whittlesey, Michael K.; Williams, Jonathan M. J.; Candito, David A.; Lautens, Mark
Organic Syntheses, 2009 , vol. 86, p. 28 - 35
3 A molecular sieve; potassium carbonate; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium in toluene T=110°C; Knoevenagel reaction; 24 h; Product distribution; Further Variations:Reagents;
参考文献
Black, Phillip. J.; Cami-Kobeci, Gerta; Edwards, Michael G.; Slatford, Paul A.; Whittlesey, Michael K.; Williams, Jonathan M. J.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 1 p. 116 - 125
