3-苄基-8-(叔丁氧基羰基)-3,8-二氮杂双环[3.2.1]-辛烷合成路线 （共 9 条）
反应条件
in dichloromethane Ambient temperature;
参考文献
Barlocco, Daniela; Cignarella, Giorgio; Tondi, Donatella; Vianello, Paola; Villa, Stefania; Bartolini, Alessandro; Ghelardini, Carla; Galeotti, Nicoletta; Anderson, David J.; Kuntzweiler, Theresa A.; Colombo, Diego; Toma, Lucio
Journal of Medicinal Chemistry, 1998 , vol. 41, # 5 p. 674 - 681
反应条件
in hexane; dichloromethane; ethyl acetate
参考文献
Pfizer Inc.
Patent: US2002/128271 A1, 2002 ;
反应条件
1: toluene / 85 °C 2: xylene / Heating 3: 230 °C 4: H2; HCl / Pd/C / H2O / 85 h / 760 Torr 5: LiAlH4 / diethyl ether / Heating 6: CH2Cl2 / 20 °C View Scheme
参考文献
Huang, Long Jiang; Teng, Da Wei
Chinese Chemical Letters, 2011 , vol. 22, # 5 p. 523 - 526
反应条件
1: xylene / Heating 2: 230 °C 3: H2; HCl / Pd/C / H2O / 85 h / 760 Torr 4: LiAlH4 / diethyl ether / Heating 5: CH2Cl2 / 20 °C View Scheme
参考文献
Smith, Stephen C; Bentley, Philip D
Tetrahedron Letters, 2002 , vol. 43, # 5 p. 899 - 902
反应条件
1: H2; HCl / Pd/C / H2O / 85 h / 760 Torr 2: LiAlH4 / diethyl ether / Heating 3: CH2Cl2 / 20 °C View Scheme
参考文献
Smith, Stephen C; Bentley, Philip D
Tetrahedron Letters, 2002 , vol. 43, # 5 p. 899 - 902
反应条件
1: LiAlH4 / diethyl ether / Heating 2: CH2Cl2 / 20 °C View Scheme
参考文献
Smith, Stephen C; Bentley, Philip D
Tetrahedron Letters, 2002 , vol. 43, # 5 p. 899 - 902
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 0.08 h / 0 - 20 °C 2: 10 palladium on activated charcoal; hydrogen / methanol / 4 h / 40 °C / 3102.97 Torr 3: triethylamine / dichloromethane / 20 °C 4: acetonitrile / Reflux View Scheme
参考文献
Huang, Long Jiang; Teng, Da Wei
Chinese Chemical Letters, 2011 , vol. 22, # 5 p. 523 - 526
反应条件
in acetonitrile Reflux;
参考文献
Huang, Long Jiang; Teng, Da Wei
Chinese Chemical Letters, 2011 , vol. 22, # 5 p. 523 - 526
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Barlocco, Daniela; Cignarella, Giorgio; Tondi, Donatella; Vianello, Paola; Villa, Stefania; Bartolini, Alessandro; Ghelardini, Carla; Galeotti, Nicoletta; Anderson, David J.; Kuntzweiler, Theresa A.; Colombo, Diego; Toma, Lucio
Journal of Medicinal Chemistry, 1998 , vol. 41, # 5 p. 674 - 681
