二(N-苄氧羰基四丙氨酰)玫瑰精合成路线 （共 4 条）
反应条件
N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine in dichloromethane 1.) 4 deg C, 2 h, 2.) room temperature, 2 d;
参考文献
Johnson, Arthur F.; Struthers, Mary D.; Pierson, Keith B.; Mangel, Walter F.; Smith, Lloyd M.
Analytical Chemistry, 1993 , vol. 65, # 17 p. 2352 - 2359
反应条件
1: 78 percent / pyridine, DMF, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / 1.) 4 deg C, 2 h, 2.) room temperature, 2 d 2: 84 percent / aq. HBr, acetic acid / 0.67 h / Ambient temperature 3: 33 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, triethylamine / CH2Cl2 / 1.) 4 deg C, 2 h, 2.) room temperature, 2 d View Scheme
参考文献
Johnson, Arthur F.; Struthers, Mary D.; Pierson, Keith B.; Mangel, Walter F.; Smith, Lloyd M.
Analytical Chemistry, 1993 , vol. 65, # 17 p. 2352 - 2359
反应条件
1: 78 percent / pyridine, DMF, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / 1.) 4 deg C, 2 h, 2.) room temperature, 2 d 2: 84 percent / aq. HBr, acetic acid / 0.67 h / Ambient temperature 3: 33 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, triethylamine / CH2Cl2 / 1.) 4 deg C, 2 h, 2.) room temperature, 2 d View Scheme
参考文献
Johnson, Arthur F.; Struthers, Mary D.; Pierson, Keith B.; Mangel, Walter F.; Smith, Lloyd M.
Analytical Chemistry, 1993 , vol. 65, # 17 p. 2352 - 2359
反应条件
1: 84 percent / aq. HBr, acetic acid / 0.67 h / Ambient temperature 2: 33 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, triethylamine / CH2Cl2 / 1.) 4 deg C, 2 h, 2.) room temperature, 2 d View Scheme
参考文献
Johnson, Arthur F.; Struthers, Mary D.; Pierson, Keith B.; Mangel, Walter F.; Smith, Lloyd M.
Analytical Chemistry, 1993 , vol. 65, # 17 p. 2352 - 2359
