4-甲氧基-1,3-异苯并呋喃二酮合成路线 （共 29 条）
反应条件
acetic anhydride in tetrahydrofuran 4 h; Heating / reflux;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2008/44045 A1, 2008 ;
Location in patent: Page/Page column 319-320 ;
WO 2008/044045 A1
反应条件
1: 3-Hydroxyphthalic anhydride With sodium hydride in N,N-dimethyl-formamide 0.25 h; 2: methyl iodide in DMF (N,N-dimethyl-formamide) 48 h;
参考文献
Novo Nordisk A/S
Patent: US7115624 B1, 2006 ;
Location in patent: Page/Page column 67-69 ;
US 7115624 B1
反应条件
in tetrahydrofuran 4 h; Heating / reflux;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2008/44054 A2, 2008 ;
Location in patent: Page/Page column 163-164 ;
WO 2008/044054 A2
反应条件
1: With potassium permanganate in water; tert-butyl alcohol 6 h; Reflux; 2: With hydrogenchloride in water; tert-butyl alcohol 3: With acetic anhydride 2 h; Reflux;
参考文献
Bayer CropScience AG
Patent: US2011/184188 A1, 2011 ;
Location in patent: Page/Page column 106 ;
反应条件
1: With potassium permanganate in water; tert-butyl alcohol 6 h; Reflux; 2: With hydrogenchloride in water; tert-butyl alcohol
参考文献
Bayer CropScience AG
Patent: US2011/184188 A1, 2011 ;
Location in patent: Page/Page column 106 ;
参考文献
Konno, Mitoshi; Nakae, Takahiko; Sakuyama, Shigeru; Odagaki, Yoshihiko; Nakai, Hisao; Hamanaka, Nobuyuki
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1649 - 1674
反应条件
acetic anhydride; trifluoroacetic acid 1 h; Heating;
参考文献
Rao, A. V. Rama; Chanda, Bhanu M.; Wadekar, Alpana V.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 3 p. 248 - 249
反应条件
boron trifluoride diethyl etherate in 1,2-dichloro-benzene 10 h; Heating;
参考文献
Newman, Melvin S.; Kanakarajan, Kuppusamy
Journal of Organic Chemistry, 1980 , vol. 45, # 17 p. 3523 - 3524
反应条件
1: hydrolysis 2: acetic anhydride / Heating View Scheme
参考文献
Gupta, Dahmendra N.; Hodge, Philip; Hurley, Peter N.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 391 - 394
反应条件
1: 91.8 percent / benzene / 2 h / Heating 2: 77 percent / CF3CO2H,(CH3CO)2O / 1 h / Heating View Scheme
参考文献
Rao, A. V. Rama; Chanda, Bhanu M.; Wadekar, Alpana V.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 3 p. 248 - 249
