4-(二苄基氨基)环己酮合成路线 （共 23 条）
反应条件
1.1: toluene / 2 h / Reflux 1.2: 15 - 20 °C 2.1: potassium carbonate; potassium iodide / 1-methyl-pyrrolidin-2-one / 24 h / 80 °C 3.1: hydrogenchloride; water / 2 h / 60 °C View Scheme
反应条件
1.1: tetra-(n-butyl)ammonium iodide; sodium carbonate / tetrahydrofuran / 17 h / Reflux 2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.92 h / -78 °C 2.2: -78 - 20 °C View Scheme
反应条件
1: potassium carbonate / acetonitrile / 12 h / 20 - 30 °C / Inert atmosphere 2: Jone's reagent / acetone / 0.58 h / 20 - 30 °C / Cooling with ice; Inert atmosphere View Scheme
反应条件
1.1: toluene / 2 h / Reflux 1.2: 15 - 20 °C 2.1: potassium carbonate; potassium iodide / 1-methyl-pyrrolidin-2-one / 24 h / 80 °C 3.1: hydrogenchloride; water / 2 h / 60 °C View Scheme
反应条件
1.1: 1,2-dichloro-ethane / 2 h / 20 °C / Inert atmosphere 1.2: 20 °C 1.3: 0.5 h 2.1: hydrogenchloride; water / 8 h / 100 °C 2.2: pH ~ 8 / Cooling with ice-water View Scheme
参考文献
WO2011/141180 A1, ;
WO 2011/141180 A1
反应条件
sodium tris(acetoxy)borohydride in dichloromethane T=20°C; 16 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2006/40279 A1, 2006 ;
Location in patent: Page/Page column 127-128 ;
反应条件
sodium tris(acetoxy)borohydride in dichloromethane
T=20°C; 12 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2006/18182 A1, 2006 ;
Location in patent: Page/Page column 72-73 ;
WO 2006/018182 A1
Title/Abstract Full Text Show Details
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2006/18185 A2, 2006 ;
Location in patent: Page/Page column 72-73 ;
WO 2006/018185 A2
反应条件
sodium tris(acetoxy)borohydride; potassium carbonate in dichloromethane
T=20°C; 12 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2006/18182 A1, 2006 ;
Location in patent: Page/Page column 73 ;
WO 2006/018182 A1
Title/Abstract Full Text Show Details
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2006/18185 A2, 2006 ;
Location in patent: Page/Page column 73 ;
WO 2006/018185 A2
反应条件
1.1: sodium acetate; sodium tris(acetoxy)borohydride / acetonitrile / 12 h / 20 - 30 °C / pH 6 - 7 / Inert atmosphere
1.2: pH 8
2.1: hydrogen; acetic acid / palladium 10 on activated carbon / dichloromethane; methanol / 12 h / 20 - 30 °C / 2280.15 Torr / Inert atmosphere
View Scheme
参考文献
SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.
Patent: US2012/184543 A1, 2012 ;
反应条件
sodium tris(acetoxy)borohydride in dichloromethane
T=20°C; 12 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2006/18182 A1, 2006 ;
Location in patent: Page/Page column 70 ;
WO 2006/018182 A1
Title/Abstract Full Text Show Details
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2006/18185 A2, 2006 ;
Location in patent: Page/Page column 70 ;
WO 2006/018185 A2
