4-(二苄基氨基)环己酮合成路线 （共 23 条）
反应条件
1: With hydrogenchloride; water T=100°C; 8 h; 2: With potassium carbonate in chloroform pH=~ 8; Cooling with ice-water;
参考文献
WO2011/141180 A1, ;
Page/Page column 49 ;
WO 2011/141180 A1
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-78°C; 0.916667 h; 2: With triethylamine in dichloromethane T=-78 - 20°C;
参考文献
US2011/160206 A1, ;
Page/Page column 27-28 ;
反应条件
1: With oxalic acid; dimethyl sulfoxide in dichloromethane T=-60°C; 0.25 h; 2: With triethylamine in dichloromethane T=-60°C; Heating;
参考文献
WO2012/101065 A2, ;
Page/Page column 188 ;
WO 2012/101065 A2
反应条件
triethylamine in dichloromethane
反应条件
triethylamine in dichloromethane; ethyl acetate
反应条件
1.1: K2CO3; LiI / acetonitrile / 24 h / 60 °C 1.2: 77 percent / HCl / tetrahydrofuran / 16 h / 20 °C 2.1: 10 percent / PdCl2(PPh3)2; Cs2CO3; Et3N / 24 h / 100 - 110 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 125, # 6 p. 1587 - 1594
反应条件
1.1: K2CO3; LiI / acetonitrile / 24 h / 60 °C 1.2: 77 percent / HCl / tetrahydrofuran / 16 h / 20 °C 2.1: 10 percent / PdCl2(PPh3)2; Cs2CO3; Et3N / 24 h / 100 - 110 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 125, # 6 p. 1587 - 1594
反应条件
1.1: potassium carbonate / acetonitrile / 17 h / Reflux 2.1: dimethyl sulfoxide; oxalic acid / dichloromethane / 0.25 h / -60 °C 2.2: -60 °C / Heating View Scheme
参考文献
WO2012/101065 A2, ;
WO 2012/101065 A2
反应条件
1.1: tetra-(n-butyl)ammonium iodide; sodium carbonate / tetrahydrofuran / 17 h / Reflux 2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.92 h / -78 °C 2.2: -78 - 20 °C View Scheme
反应条件
1.1: hydrogen / palladium-on-charcoal / methanol / 24 h / 60 °C 2.1: dimethyl sulfoxide; phosphorous pentoxide / dichloromethane / 1 h / 0 °C 2.2: 2 h / 0 °C 2.3: 0.67 h / 20 °C View Scheme
